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Journal of Dental Research
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Clinical

Low-fluoride Dentifrice and Gastrointestinal Fluoride Absorption after Meals

J.A. Cury*, F.S. Del Fiol, L.M.A. Tenuta and P.L. Rosalen

Faculty of Dentistry of Piracicaba, UNICAMP, Av. Limeira 901, 13414-903, Piracicaba, SP, Brazil;

Correspondence: * corresponding author, jcury{at}fop.unicamp.br

A low-fluoride (F) dentifrice has been recommended to reduce the risk of dental fluorosis, but its anti-caries efficacy is questionable compared with that of conventional dentrifices (1000–1100 µg F/g). The tested hypothesis was that conventional dentifrices might be safe if used soon after meals, since food interferes with F absorption. In a crossover, double-blind study, 11 volunteers ingested a dentifrice slurry containing 0 (placebo), 550 (low F), or 1100 µg F/g in 3 gastric content situations: on fasting, or 15 min after breakfast or lunch. F was analyzed in saliva and 24-hour urine samples. The conventional dentifrice ingested after lunch resulted in only 10% higher F absorption than the low-F ingested on fasting. Analysis of the data suggests that the risk of fluorosis could be reduced by the use of either a low-F dentifrice or a conventional dentifrice, if toothbrushing occurred soon after meals.

Key Words: fluoride • dentifrice • absorption • saliva • food

Journal of Dental Research, Vol. 84, No. 12, 1133-1137 (2005)
DOI: 10.1177/154405910508401208
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