Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Foster, N.
Right arrow Articles by Preshaw, P.M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Foster, N.
Right arrow Articles by Preshaw, P.M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Biological

VIP Inhibits Porphyromonas gingivalis LPS-induced Immune Responses in Human Monocytes

N. Foster*, J. Cheetham, J.J. Taylor and P.M. Preshaw

Oral Microbiology and Host Responses Group, School of Dental Sciences, University of Newcastle Upon Tyne, NE2 4BW, UK;

Correspondence: * corresponding author, neil.foster{at}ncl.ac.uk

Lipopolysaccharide (LPS) from the Gram-negative pathogen Porphyromonas gingivalis (Pg) stimulates cytokine secretion in immune cells, and thereby initiates the inflammation associated with periodontitis. Modulation of pro-inflammatory cytokine activity is a plausible therapeutic target in periodontal disease. Vasoactive intestinal peptide (VIP) has a role in immunoregulation, and has been identified as a molecule with therapeutically beneficial immunosuppressive effects in inflammatory and autoimmune conditions. We aimed to investigate the effect of VIP on immune responses induced by Pg LPS in vitro. VIP (10–8 M) significantly (P < 0.05) inhibits TNF-{alpha} production by human monocytic THP1 cells stimulated with Pg LPS. In parallel, we showed that VIP inhibits nuclear translocation of NF{kappa}B and c-Jun in a time-dependent manner, but does not decrease the expression of CD14 receptors. This is the first report to show the potential of VIP as an immunomodulator of Pg-stimulated inflammatory pathways in human monocytes.

Key Words: monocyte • VIP • Porphyromonas gingivalis • LPS

Journal of Dental Research, Vol. 84, No. 11, 999-1004 (2005)
DOI: 10.1177/154405910508401106
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
H. F. Rosenberg
Vasoactive intestinal peptide, periodontal disease, and the innate immune response: an interview with Dr. John J. Taylor
J. Leukoc. Biol., April 1, 2007; 81(4): 904 - 906.
[Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
N. Foster, S. R. Lea, P. M. Preshaw, and J. J. Taylor
Pivotal Advance: Vasoactive intestinal peptide inhibits up-regulation of human monocyte TLR2 and TLR4 by LPS and differentiation of monocytes to macrophages
J. Leukoc. Biol., April 1, 2007; 81(4): 893 - 903.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
H. Welkerling, W. Geissdorfer, T. Aigner, and R. Forst
Osteomyelitis of the Ulna Caused by Porphyromonas gingivalis.
J. Clin. Microbiol., October 1, 2006; 44(10): 3835 - 3837.
[Abstract] [Full Text] [PDF]


Journal of Dental Research Call for Editor