This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Koo, H. Articles by Park, Y.K. Search for Related Content PubMed PubMed Citation Articles by Koo, H. Articles by Park, Y.K. Social Bookmarking                         What's this?

Apigenin and tt-Farnesol with Fluoride Effects on S. mutans Biofilms and Dental Caries

¹ Center for Oral Biology and
² Eastman Department of Dentistry, University of Rochester Medical Center, 625 Elmwood Ave., Box 683, Rochester, NY 14620, USA; and
³ Department of Physiological Sciences, Faculty of Dentistry of Piracicaba, and Department of Food Science, College of Food Engineering, State University of Campinas, SP, Brazil;

Correspondence: ^* corresponding author, Hyun_Koo{at}urmc.rochester.edu

Apigenin (Api) and tt-farnesol (Far) are two naturally occurring agents that affect the development of cariogenic biofilms. Fluoride (F) interferes physicochemically with caries development and also exhibits antibacterial activity. We examined whether the association of Api and Far enhance the anti-caries properties of F by acting cooperatively on the expression of virulence of Streptococcus mutans. The biological effects of each of the agents were greatly enhanced when used in combination with F. In general, biofilms treated with Api and/or Far in combination with F displayed less biomass and fewer insoluble glucans and iodophilic polysaccharides than did those treated with the test agents alone (P < 0.05). The combination of the test agents with F was highly effective in preventing caries development in rats, especially Api+Far+F, and results were comparable with those observed with chlorhexidine + F (positive control). Results from these studies showed that apigenin and tt-farnesol may enhance the cariostatic effectiveness of fluoride.

Key Words: apigenin • tt-farnesol • fluoride • S. mutans • biofilms.

Journal of Dental Research, Vol. 84, No. 11, 1016-1020 (2005)
DOI: 10.1177/154405910508401109


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				F. Chen, X.-M. Liu, K. C. Rice, X. Li, F. Yu, R. A. Reinhardt, K. W. Bayles, and D. Wang Tooth-Binding Micelles for Dental Caries Prevention Antimicrob. Agents Chemother., November 1, 2009; 53(11): 4898 - 4902. [Abstract] [Full Text] [PDF]

				A. Unnanuntana, L. Bonsignore, M. E. Shirtliff, and E. M. Greenfield The Effects of Farnesol on Staphylococcus aureus Biofilms and Osteoblasts. An in Vitro Study J. Bone Joint Surg. Am., November 1, 2009; 91(11): 2683 - 2692. [Abstract] [Full Text] [PDF]

				J.M. B. ten Cate The Need for Antibacterial Approaches to Improve Caries Control Advances in Dental Research, August 1, 2009; 21(1): 8 - 12. [Full Text] [PDF]

				H. Koo and J. G. Jeon Naturally Occurring Molecules as Alternative Therapeutic Agents against Cariogenic Biofilms Advances in Dental Research, August 1, 2009; 21(1): 63 - 68. [Full Text] [PDF]

				M. I. Klein, S. Duarte, J. Xiao, S. Mitra, T. H. Foster, and H. Koo Structural and Molecular Basis of the Role of Starch and Sucrose in Streptococcus mutans Biofilm Development Appl. Envir. Microbiol., February 1, 2009; 75(3): 837 - 841. [Abstract] [Full Text] [PDF]

				H. Koo Strategies to Enhance the Biological Effects of Fluoride on Dental Biofilms Advances in Dental Research, July 1, 2008; 20(1): 17 - 21. [Full Text] [PDF]