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Journal of Dental Research
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Biomaterials & Bioengineering

Inhibition of Root Caries Progression by an Antibacterial Adhesive

A. Kuramoto1, S. Imazato1,*, A.W.G. Walls2 and S. Ebisu1

1 Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8, Yamadaoka, Suita, Osaka 565-0871, Japan; and
2 Department of Restorative Dentistry, Dental School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK;

Correspondence: * corresponding author, imazato{at}dent.osaka-u.ac.jp

A dentin primer containing the antibacterial monomer 12-methacryloyloxydodecylpyridinium bromide (MDPB) has been shown to penetrate and kill the bacteria in artificially demineralized dentin. We hypothesized that an experimental adhesive system, which incorporates the MDPB-containing primer, would be effective in inhibiting the progression of root caries in vitro. Artificial caries lesions were prepared by either an acid-gel or a Streptococcus mutans culture technique on the roots of extracted human teeth. The progression of these lesions after the application of the experimental or proprietary adhesive system was examined. Further demineralization was completely prevented by the experimental adhesive system, while lesions managed with the proprietary materials showed limited ability to inhibit further demineralization. We conclude that the experimental adhesive system can inhibit the progression of root-surface caries in vitro, through a combination of its antimicrobial activity and sealing of the demineralized dentin.

Key Words: root-surface caries • demineralization • adhesive system • antibacterial effects • artificial caries

Journal of Dental Research, Vol. 84, No. 1, 89-93 (2005)
DOI: 10.1177/154405910508400116
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