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Expression of SIBLINGs and Their Partner MMPs in Salivary Glands
K.U.E. Ogbureke and
L.W. Fisher*
Craniofacial and Skeletal Diseases Branch, Building 30, Room 228, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, 9000 Rockville Pike, Bethesda, MD 20892-4320, USA;
Correspondence: * corresponding author, lfisher{at}dir.nidcr.nih.gov
Three members of the SIBLING family of integrin-binding phosphoglycoproteins (bone sialoprotein, BSP; osteopontin, OPN; and dentin matrix protein-1, DMP1) were recently shown to bind with high affinity (nM) and to activate 3 different matrix metalloproteinases (MMP-2, MMP-3, and MMP-9, respectively) in vitro. The current study was designed to document the possible biological relevance of the SIBLING-MMP activation pathway in vivo by showing that these 3 SIBLINGs and their known MMP partners are co-expressed in normal adult tissue. BSP, OPN, and DMP1 were invariably co-expressed with their partner MMPs in salivary glands of humans and mice. The 2 SIBLING proteins without known MMP partners, dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE), were also expressed in salivary glands. Expression of all SIBLINGs in this normal, non-mineralizing epithelial tissue suggests that they serve at least one function in vivo other than directly promoting matrix mineralization—a function we hypothesize involves local activation of MMPs.
Key Words: SIBLING • MMP • bone sialoprotein • osteopontin • dentin matrix protein-1
Journal of Dental Research, Vol. 83, No. 9,
664-670 (2004)
DOI: 10.1177/154405910408300902
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