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Journal of Dental Research
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Clinical

Salivary Agglutinin/DMBT1SAG Expression is Up-regulated in the Presence of Salivary Gland Tumors

F.J. Bikker1, J.E. van der Wal2, A.J.M. Ligtenberg1,*, J. Mollenhauer3, J.M.A. de Blieck-Hogervorst1, I. van der Waal4, A. Poustka3 and A.V. Nieuw Amerongen1

1 Department of Dental Basic Sciences, Academic Centre for Dentistry Amsterdam (ACTA), Van der Boechorststraat 7, 1081 BT Amsterdam, the Netherlands;
2 Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands;
3 Department of Molecular Genome Analysis, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany; and
4 Department of Oral & Maxillofacial Surgery and Oral Pathology, Free University medical centre (VUmc)/ACTA, Amsterdam, the Netherlands;

Correspondence: * corresponding author, ajm.ligtenberg{at}vumc.nl

Salivary agglutinin (SAG) is encoded by the gene Deleted in Malignant Brain Tumors 1 (DMBT1) and represents the salivary variant of DMBT1 (DMBT1SAG). While SAG is a bona fide anti-caries factor, DMBT1 was proposed as a candidate tumor-suppressor for brain, digestive tract, and lung cancer. Though DMBT1SAG is expressed in the salivary glands, its expression in salivary gland tumors is unknown. Here we analyzed DMBT1SAG expression in 20 salivary gland tumors and 14 tumor-flanking tissues by immunohistochemistry. DMBT1SAG in salivary gland tumors resembles the changes of expression levels known from DMBT1 in tumors in other cancer types. Particularly, DMBT1SAG was up-regulated in 10/14 tumor-flanking tissues, and a strong staining of the luminal content in the tumor and/or the tumor-flanking tissue was observed in 14/20 cases. This suggests that, in addition to its role in caries defense, SAG may serve as a potential tumor indicator and/or tumor suppressor in salivary gland tissue.

Key Words: DMBT1 • gp-340 • salivary agglutinin • SRCR • salivary gland tumor

Journal of Dental Research, Vol. 83, No. 7, 567-571 (2004)
DOI: 10.1177/154405910408300711
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