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Journal of Dental Research
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Biological

Indian Hedgehog: A Mechanotransduction Mediator in Condylar Cartilage

G.H. Tang1,2, A.B.M. Rabie1,* and U. Hägg1

1 Hard Tissue Biology and Repair Research Group and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong SAR, China; and
2 Department of Orthodontics, School of Stomatology, Shanghai Second Medical University, Shanghai, China;

Correspondence: * corresponding author, rabie{at}hkusua.hku.hk

Indian hedgehog (Ihh) is a critical mediator transducing mechanical signals to stimulate chondrocyte proliferation. To clarify the cellular signal transduction pathway that senses and converts mechanical signals into tissue growth in mandibular condyle, we evaluated Ihh expression and its relation to the kinetics of replicating mesenchymal cells in condylar cartilage during natural growth and mandibular advancement. Thirty-five-day-old Sprague-Dawley rats were fitted with functional appliances. Experimental animals with matched controls were doubly labeled with iododeoxyuridine and bromodeoxyuridine so that we could evaluate the cycles of the proliferative mesenchymal cells. Mandibular advancement triggered Ihh expression in condylar cartilage. A higher level of Ihh expression coincided with the increase of the replicating mesenchymal cells’ population and the shortening of the turnover time. These findings suggested that Ihh acts as a mediator of mechanotransduction that converts mechanical signals resulting from anterior mandibular displacement to stimulate cellular proliferation in condylar cartilage.

Key Words: Ihh • condylar cartilage • proliferation • mechanical stress • cell cycle

Journal of Dental Research, Vol. 83, No. 5, 434-438 (2004)
DOI: 10.1177/154405910408300516
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