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Journal of Dental Research
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Biomaterials & Bioengineering

Collagen Degradation in Endodontically Treated Teeth after Clinical Function

M. Ferrari1, P.N. Mason2, C. Goracci1, D.H. Pashley3 and F.R. Tay1,4,*

1 Dental Materials and Restorative Dentistry Department, University of Siena, Italy;
2 Restorative Dentistry Department, University of Padua, Italy;
3 Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, GA 30912-1129, USA; and
4 Pediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong SAR, China;

Correspondence: * corresponding author, kfctay{at}netvigator.com

Endodontically treated teeth restored with posts are susceptible to coronal leakage after long-term function. We hypothesize that demineralized collagen matrices (DCMs) created in dentin by acidic zinc phosphate cement within the dowel spaces degrade with time. Forty-two post-restored teeth were extracted after three periods of clinical service and were examined, by means of scanning and transmission electron microscopy, for the status of the DCMs. SEM revealed a progressive degradation of the DCMs, becoming less dense after 3 to 5 years, losing structural integrity after 6 to 9 years, and partially disappearing after 10 to 12 years. TEM revealed evidence of collagenolytic activity within the DCMs, with loss of cross-banding and unraveling into microfibrils, and gelatinolytic activity that resulted in disintegration of the microfibrils. Bacterial colonization and the release of bacterial enzymes and of host-derived matrix metalloproteinases may contribute to the degradation of collagen fibrils in root dentin after clinical function.

Key Words: In vivo • root dentin • collagen fibrils • bacteria • matrix metalloproteinases

Journal of Dental Research, Vol. 83, No. 5, 414-419 (2004)
DOI: 10.1177/154405910408300512
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