Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ruwanpura, S.M.P.M.
Right arrow Articles by Ishikawa, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ruwanpura, S.M.P.M.
Right arrow Articles by Ishikawa, I.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biological

Prostaglandin E2 Regulates Interleukin-1β-induced Matrix Metalloproteinase-3 Production in Human Gingival Fibroblasts

S.M.P.M. Ruwanpura1,2,*, K. Noguchi1,2 and I. Ishikawa1,2

1 Periodontology, Department of Hard Tissue Engineering, Graduate School, and 2 Centre of Excellence Program for Frontier Research on Molecular Destruction of Tooth and Bone, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8549, Japan;

Correspondence: * corresponding author, pradeepruwanpura.peri{at}tmd.ac.jp

Prostaglandin E2 (PGE2) exerts its biological actions via EP receptors (EP1, EP2, EP3, and EP4). In the present study, we investigated whether PGE2 regulated interleukin (IL)-1β-induced matrix metalloproteinase (MMP)-3 production in human gingival fibroblasts (HGF) derived from periodontally healthy subjects and diseased patients. In HGF from healthy gingiva, PGE2 down-regulated IL-1β-induced MMP-3 production, whereas in HGF from periodontitis patients, PGE2 enhanced it. Butaprost (an EP2 agonist) and ONO-AE1-329 (an EP4 agonist) suppressed IL-1β-induced MMP-3 production, and 17-phenyl-{omega}-trinor PGE2 (an EP1 agonist) mimicked the PGE2 effect in HGF from healthy and periodontally diseased tissues, respectively. Analysis of these data suggests that, in HGF from healthy tissue, IL-1β-induced MMP-3 production is down-regulated by PGE2 via EP2 and EP4 receptors, whereas in cells from periodontally diseased tissue, IL-1β-induced MMP-3 production is up-regulated via EP1 receptors. Different regulation of IL-1β-induced MMP-3 production by PGE2 between healthy and periodontally diseased tissues may be involved in the pathogenesis of periodontal disease.

Key Words: human gingival fibroblasts • interleukin-1β • matrix metalloproteinase-3 • prostaglandin E2 • EP receptors

Journal of Dental Research, Vol. 83, No. 3, 260-265 (2004)
DOI: 10.1177/154405910408300315
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
E. Kunisch, A. Jansen, F. Kojima, I. Loffler, M. Kapoor, S. Kawai, I. Rubio, L. J. Crofford, and R. W. Kinne
Prostaglandin E2 Differentially Modulates Proinflammatory/Prodestructive Effects of TNF-{alpha} on Synovial Fibroblasts via Specific E Prostanoid Receptors/cAMP
J. Immunol., July 15, 2009; 183(2): 1328 - 1336.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M.-H. Wu, Y. Shoji, M.-C. Wu, P.-C. Chuang, C.-C. Lin, M.-F. Huang, and S.-J. Tsai
Suppression of Matrix Metalloproteinase-9 by Prostaglandin E2 in Peritoneal Macrophage Is Associated with Severity of Endometriosis
Am. J. Pathol., October 1, 2005; 167(4): 1061 - 1069.
[Abstract] [Full Text] [PDF]