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Journal of Dental Research
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Biological

Effects of Sex Hormone Disturbances on Craniofacial Growth in Newborn Mice

T. Fujita*, J. Ohtani, M. Shigekawa, T. Kawata, M. Kaku, S. Kohno, K. Tsutsui, K. Tenjo, M. Motokawa, Y. Tohma and K. Tanne

Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;

Correspondence: * corresponding author, seven{at}hiroshima-u.ac.jp

It is well-known that sex hormones influence bone metabolism. However, it remains unclear as to how sex hormones affect bone growth in newborn mice. In this study, we performed orchiectomy (ORX) and ovariectomy (OVX) on newborn mice, and examined the effects on craniofacial growth morphometrically. ORX and OVX were performed on five-day-old C57BL/6J mice. Four weeks after surgery, lateral cephalograms were taken of all of the mice, with the use of a rat and mouse cephalometer. Cephalometric analysis of the craniofacial skeleton was performed by means of a personal computer. Inhibition of craniofacial growth was found in the experimental groups but not in the sham-operated groups. In the nasomaxillary bone and mandible, the amount of growth was significantly reduced. These results suggest that craniofacial growth is inhibited by sex hormone disturbances not only in puberty but also immediately after birth.

Key Words: orchiectomy • ovariectomy • craniofacial growth • newborn mice

Journal of Dental Research, Vol. 83, No. 3, 250-254 (2004)
DOI: 10.1177/154405910408300313
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T. Fujita, J. Ohtani, M. Shigekawa, T. Kawata, M. Kaku, S. Kohno, M. Motokawa, Y. Tohma, and K. Tanne
Influence of sex hormone disturbances on the internal structure of the mandible in newborn mice
Eur J Orthod, April 1, 2006; 28(2): 190 - 194.
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