Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Joshipura, K.J.
Right arrow Articles by Rimm, E.B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Joshipura, K.J.
Right arrow Articles by Rimm, E.B.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*ACETYLSALICYLIC ACID
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Clinical

Periodontal Disease and Biomarkers Related to Cardiovascular Disease

K.J. Joshipura1,2,*, H.C. Wand3, A.T. Merchant1,4 and E.B. Rimm2,4,5

1 Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine;
2 Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA;
3 Department of Biostatistics, Harvard School of Public Health;
4 Department of Nutrition, Harvard School of Public Health; and
5 Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital;

Correspondence: * corresponding author, kjoshipura{at}hsdm.harvard.edu

Periodontal disease is a chronic infection of the gums characterized by a loss of attachment between the tooth and bone, and by bone loss. We evaluated cross-sectionally the association between periodontal disease and C-reactive protein (CRP), fibrinogen, factor VII, tissue plasminogen activator (t-PA), LDL-C, von Willebrand factor, and soluble tumor necrosis factor receptors 1 and 2. The final sample consisted of 468 men (ages 47–80 yrs), participating in the Health Professional Follow-up Study, who provided blood and were free of CVD, diabetes, and cancer. In multivariate regression models controlling for age, cigarette smoking, alcohol intake, physical activity, and aspirin intake, self-reported periodontal disease was associated with significantly higher levels of CRP (30% higher among periodontal cases compared with non-cases), t-PA (11% higher), and LDL-C (11% higher). Based on our data, periodontal disease showed significant associations with biomarkers of endothelial dysfunction and dyslipidemia, which may potentially mediate the association between periodontal and cardiovascular disease.

Key Words: periodontal disease • tooth loss • cardiovascular disease • biomarkers • inflammation

Journal of Dental Research, Vol. 83, No. 2, 151-155 (2004)
DOI: 10.1177/154405910408300213
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
L. A. Mucci, C.-c. Hsieh, P. L. Williams, M. Arora, H.-O. Adami, U. de Faire, C. W. Douglass, and N. L. Pedersen
Do Genetic Factors Explain the Association Between Poor Oral Health and Cardiovascular Disease? A Prospective Study Among Swedish Twins
Am. J. Epidemiol., September 1, 2009; 170(5): 615 - 621.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
P. Bullon, J.M. Morillo, M.C. Ramirez-Tortosa, J.L. Quiles, H.N. Newman, and M. Battino
Metabolic Syndrome and Periodontitis: Is Oxidative Stress a Common Link?
Journal of Dental Research, June 1, 2009; 88(6): 503 - 518.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. Suzuki, E. Bayna, H. L. Li, E. D. Molle, and W. Y.W. Lew
Lipopolysaccharide Activates Calcineurin in Ventricular Myocytes
J. Am. Coll. Cardiol., January 30, 2007; 49(4): 491 - 499.
[Abstract] [Full Text] [PDF]

Home page
 Journal of the American Dental AssociationHome page
C. O. Enwonwu and C. S. Ritchie
Nutrition and inflammatory markers
J Am Dent Assoc, January 1, 2007; 138(1): 70 - 73.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
P. H. Rodrigues and A. Progulske-Fox
Gene Expression Profile Analysis of Porphyromonas gingivalis during Invasion of Human Coronary Artery Endothelial Cells
Infect. Immun., September 1, 2005; 73(9): 6169 - 6173.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
A. Chait, C. Y. Han, J. F. Oram, and J. W. Heinecke
Thematic review series: The Immune System and Atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease?
J. Lipid Res., March 1, 2005; 46(3): 389 - 403.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
J. H. Meurman, M. Sanz, and S.-J. Janket
ORAL HEALTH, ATHEROSCLEROSIS, AND CARDIOVASCULAR DISEASE
Critical Reviews in Oral Biology & Medicine, November 1, 2004; 15(6): 403 - 413.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Taguchi, M. Sanada, Y. Suei, M. Ohtsuka, K. Lee, K. Tanimoto, M. Tsuda, K. Ohama, M. Yoshizumi, and Y. Higashi
Tooth Loss Is Associated With an Increased Risk of Hypertension in Postmenopausal Women
Hypertension, June 1, 2004; 43(6): 1297 - 1300.
[Abstract] [Full Text] [PDF]