Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Gao, Y.
Right arrow Articles by Lukinmaa, P.-L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gao, Y.
Right arrow Articles by Lukinmaa, P.-L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biological

Lactational Exposure of Han/Wistar Rats to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Interferes with Enamel Maturation and Retards Dentin Mineralization

Y. Gao1,8,9, C. Sahlberg1,9,10, A. Kiukkonen1, S. Alaluusua1,2, R. Pohjanvirta3,4,5, J. Tuomisto5 and P.-L. Lukinmaa6,7

1 Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Finland;
2 Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Finland;
3 Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, University of Helsinki, Finland;
4 Kuopio Department, National Veterinary and Food Research Institute, Finland;
5 Department of Environmental Health, National Public Health Institute, Kuopio, Finland;
6 Department of Oral Pathology, Institute of Dentistry, University of Helsinki, Finland;
7 Department of Pathology, Helsinki University Central Hospital, Finland;

Correspondence: 10 corresponding author, Institute of Dentistry, Biomedicum Helsinki, PO Box 63, FIN-00014 UNIVERSITY OF HELSINKI, Finland, carin.sahlberg{at}helsinki.fi

Exposure to environmental dioxins via mother’s milk may be one causative factor of mineralization defects in children’s teeth. A prerequisite for the completion of enamel mineralization is the removal of enamel matrix. To test the hypothesis that dioxins interfere with enamel maturation, we administered lactating Han/Wistar rats a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 50 or 1000 µg/kg) on the day after delivery and analyzed tissue sections of the pup heads at post-natal days (Pn) 9 and 22. By Pn22, the first and second molars of the exposed pups, but not controls, showed retention of enamel matrix. Predentin was thicker than normal. Immunostaining for the aryl hydrocarbon/dioxin receptor (AhR) and cytochrome P4501A1 (CYP1A1) in ameloblasts and odontoblasts was reduced, suggesting that TCDD interferes with tooth mineralization via AhR. Extinction of AhR may lead to abolition of CYP1A1 expression as a sign of impaired dental cell function.

Key Words: TCDD • enamel maturation • dentin mineralization • AhR • CYP1A1

Journal of Dental Research, Vol. 83, No. 2, 139-144 (2004)
DOI: 10.1177/154405910408300211
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Orthod.Home page
N. Kilpatrick
New developments in understanding development defects of enamel: optimizing clinical outcomes
J. Orthod., October 1, 2009; 36(4): 277 - 282.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
E. Salmela, C. Sahlberg, S. Alaluusua, and P.-L. Lukinmaa
Tributyltin Impairs Dentin Mineralization and Enamel Formation in Cultured Mouse Embryonic Molar Teeth
Toxicol. Sci., November 1, 2008; 106(1): 214 - 222.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
K. Yoshizawa, A. Heatherly, D. E. Malarkey, N. J. Walker, and A. Nyska
A Critical Comparison of Murine Pathology and Epidemiological Data of TCDD, PCB126, and PeCDF
Toxicol Pathol, December 1, 2007; 35(7): 865 - 879.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
E. Peltonen, P.-L. Lukinmaa, C. Sahlberg, A.-M. Partanen, A. Kiukkonen, and S. Alaluusua
7,12-Dimethylbenz[a]anthracene Interferes with the Development of Cultured Mouse Mandibular Molars
Toxicol. Sci., July 1, 2006; 92(1): 279 - 285.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
H. M. Miettinen, R. Sorvari, S. Alaluusua, M. Murtomaa, J. Tuukkanen, and M. Viluksela
The Effect of Perinatal TCDD Exposure on Caries Susceptibility in Rats
Toxicol. Sci., June 1, 2006; 91(2): 568 - 575.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
K. Yoshizawa, N. J. Walker, M. P. Jokinen, A. E. Brix, D. M. Sells, T. Marsh, M. E. Wyde, D. Orzech, J. K. Haseman, and A. Nyska
Gingival Carcinogenicity in Female Harlan Sprague-Dawley Rats following Two-Year Oral Treatment with 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Dioxin-Like Compounds
Toxicol. Sci., January 1, 2005; 83(1): 64 - 77.
[Abstract] [Full Text] [PDF]