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Journal of Dental Research
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Biomaterials & Bioengineering

Antibacterial Titanium Plate Anodized by being Discharged in NaCl Solution Exhibits Cell Compatibility

Y. Shibata*, H. Kawai, H. Yamamoto, T. Igarashi1 and T. Miyazaki

Department of Oral Biomaterials and Technology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan; and
1 Department of Oral Microbiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan;

Correspondence: * corresponding author, yookun{at}dent.showa-u.ac.jp

Implant surfaces should be modified to achieve excellent cell compatibility as well as antibacterial activity. Our previous study demonstrated that titanium plates anodized by being discharged in NaCl (Ti-Cl) exhibited high antibacterial activity. Since Ti-Cl was prepared with a NaCl solution, we hypothesized that Ti-Cl would exhibit low toxicity toward cells. The aims of this study were to characterize the surface of Ti-Cl and investigate the cell compatibility (MC3T3-E1 and L929 cells) of Ti-Cl. The results demonstrated that, since the TiCl3 formed on the Ti-Cl surface was hydrolyzed into HCl, HClO, and TiOH after immersion in pure distilled water, TiCl3 contributed to the antibacterial activity of Ti-Cl. On the other hand, TiO formed on the Ti-Cl surface enhanced cell extension and cell growth through a larger adsorption of fibronectin compared with the pure titanium control. These findings suggest that antibacterial titanium is a promising material for use in dental implant systems.

Key Words: titanium • anodizing • oral bacteria • antibacterial activity

Journal of Dental Research, Vol. 83, No. 2, 115-119 (2004)
DOI: 10.1177/154405910408300206
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S. Omori, Y. Shibata, T. Arimoto, T. Igarashi, K. Baba, and T. Miyazaki
Micro-organism and Cell Viability on Antimicrobially Modified Titanium
Journal of Dental Research, October 1, 2009; 88(10): 957 - 962.
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