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Journal of Dental Research
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Biomaterials & Bioengineering

Blue Light Differentially Modulates Cell Survival and Growth

J.C. Wataha1,*, J.B. Lewis1, P.E. Lockwood1, S. Hsu1, R.L. Messer1, F.A. Rueggeberg1 and S. Bouillaguet2

1 Department of Oral Rehabilitation, Medical College of Georgia School of Dentistry, Augusta, GA 30912-1260; and
2 University of Geneva School of Dental Medicine, Geneva, Switzerland;

Correspondence: * corresponding author, watahaj{at}mail.mcg.edu

Previous studies have reported that blue light (400–500 nm) inhibits cell mitochondrial activity. We investigated the hypothesis that cells with high energy consumption are most susceptible to blue-light-induced mitochondrial inhibition. We estimated cell energy consumption by population doubling time, and cell survival and growth by succinate dehydrogenase (SDH) activity. Six cell types were exposed to 5 or 60 J/cm2 of blue light from quartz-tungsten-halogen (QTH), plasma-arc (PAC), or argon laser sources in monolayer culture. Post-light SDH activity correlated positively with population doubling time (R2 = 0.91 for PAC, 0.76 for QTH, 0.68 for laser); SDH activity increased for cell types with the longest doubling times and was suppressed for cell types with shorter doubling times. Thus, light-induced exposure differentially affects SDH activity, cell survival, and growth, depending on cell energy consumption. Blue light may be useful as a therapeutic modulator of cell growth and survival.

Key Words: visible light • in vitro • MTT • fibroblasts • keratinocytes

Journal of Dental Research, Vol. 83, No. 2, 104-108 (2004)
DOI: 10.1177/154405910408300204
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