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The Highly Leukotoxic JP2 Clone of Actinobacillus actinomycetemcomitans and Progression of Periodontal Attachment Loss

¹ Department of Community Oral Health and Pediatric Dentistry, Dental School, Faculty of Health Sciences, University of Aarhus, Vennelyst Boulevard, DK 8000 Aarhus C, Denmark; ² Department of Medical Microbiology and Immunology, University of Aarhus, Denmark; and ³ Dental Faculty, University of Rabat, Morocco;

Correspondence: ^* corresponding author, dhaubek{at}odont.au.dk

The JP2 clone of Actinobacillus actinomycetemcomitans has been implicated in the etiology of periodontitis in adolescents. The aim of this two-year longitudinal study was to describe clinical attachment loss (CAL) progression and to assess its association with baseline occurrence of the JP2 and non-JP2 types of A. actinomycetemcomitans. Clinical re-examination of 121 adolescents in Morocco was performed. Progression of CAL 1 mm, 2 mm, 3 mm, and 4 mm on at least one site was found in 58%, 48%, 22%, and 6% of the subjects, respectively. Subjects who, at baseline, harbored the JP2 clone had a significantly higher progression of CAL than did subjects harboring non-JP2 types of A. actinomycetemcomitans. Subjects harboring non-JP2 types displayed a marginally higher CAL progression than did subjects who were culture-negative for A. actinomycetemcomitans.

Key Words: Actinobacillus actinomycetemcomitans • leukotoxin • Morocco • progression • adolescent

Journal of Dental Research, Vol. 83, No. 10, 767-770 (2004)
DOI: 10.1177/154405910408301006


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