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Journal of Dental Research
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Biological

Mouse Cellular Cementum is Highly Dependent on Growth Hormone Status

J.R. Smid1,*, J.E. Rowland2, W.G. Young1, T.J. Daley1, K.T. Coschigano4, J.J. Kopchick4,5 and M.J. Waters2,3

1 School of Dentistry,
2 School of Biomedical Sciences, and
3 Institute for Molecular Bioscience, University of Queensland, St. Lucia, Brisbane, Queensland 4072, Australia;
4 Edison Biotechnology Institute; and
5 Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, OH, USA;

Correspondence: * corresponding author, j.smid{at}mailbox.uq.edu.au

Cementum is known to be growth-hormone (GH)-responsive, but to what extent is unclear. This study examines the effects of extremes of GH status on cementogenesis in three lines of genetically modified mice; GH excess (giant), GH antagonist excess (dwarf), and GH receptor-deleted (GHR-KO) (dwarf). Age-matched mandibular molar tissues were processed for light microscope histology. Digital images of sections of first molar teeth were captured for morphometric analysis of lingual root cementum. Cross-sectional area of the cellular cementum was a sensitive guide to GH status, being reduced nearly 10-fold in GHR-KO mice, three-fold in GH antagonist mice, and increased almost two-fold in giant mice (p < 0.001). Cellular cementum length was similarly influenced by GH status, but to a lesser extent. Acellular cementum was generally unaffected. This study reveals cellular cementum to be a highly responsive GH target tissue, which may have therapeutic applications in assisting regeneration of the periodontium.

Key Words: cementum • growth hormone • GH transgenic mice • GH receptor knockout mice

Journal of Dental Research, Vol. 83, No. 1, 35-39 (2004)
DOI: 10.1177/154405910408300107
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G. O. Ramirez-Yanez, J. R. Smid, W. G. Young, and M. J. Waters
Influence of growth hormone on the craniofacial complex of transgenic mice
Eur J Orthod, October 1, 2005; 27(5): 494 - 500.
[Abstract] [Full Text] [PDF]