Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Postiglione, L.
Right arrow Articles by Rossi, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Postiglione, L.
Right arrow Articles by Rossi, G.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*TITANIUM
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biomaterials & Bioengineering

Behavior of SaOS-2 Cells Cultured on Different Titanium Surfaces

L. Postiglione1,*, G. Di Domenico1, L. Ramaglia2, S. Montagnani3, S. Salzano4, F. Di Meglio3, L. Sbordone5, M. Vitale1 and G. Rossi1

1 Dept. of Cellular and Molecular Biology and Pathology, "L. Califano",
2 Dept. of Dental and Maxillofacial Sciences,
3 Dept. of Biomorphological Sciences, and
4 CNR/IEOS "G. Salvatore", University of Naples "Federico II", via S. Pansini 5, 80131 Naples, Italy; and
5 Dept. of Periodontics, University of Pisa, Italy;

Correspondence: * corresponding author, lorposti{at}unina.it

Surface properties may affect the clinical outcome of titanium dental implants. The aim of the present study was to investigate the effects of 3 different titanium surfaces—smooth (S), sandblasted (SB), and titanium plasma-sprayed (TPS)—on proliferation, differentiation, and apoptosis of human osteoblast-like cells, SaOS-2. Cell proliferation was significantly (p < 0.05) higher on the S surface, and synthesis of extracellular matrix proteins was more abundant on TPS and SB than on S surfaces. Analysis of integrin receptors showed a higher expression of {alpha}2, {alpha}5, {alpha}Vβ3, and ß1 on TPS as compared with SB and S surfaces. An increase in alkaline phosphatase activity was detected only on SB and TPS surfaces. Analysis of cell apoptosis did not demonstrate any significant difference among the 3 different surfaces. The results indicate that titanium surface topography affects proliferation and differentiation of osteoblast-like SaOS-2 cells, suggesting that surface properties might be important for bone response around dental implants in vivo.

Key Words: titanium surfaces • osteoblasts • cell growth • cell differentiation • cell apoptosis

Journal of Dental Research, Vol. 82, No. 9, 692-696 (2003)
DOI: 10.1177/154405910308200907
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?