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Biomaterials & Bioengineering

Galanin-immunoreactive Nerve Fibers in the Periodontal Ligament during Experimental Tooth Movement

T. Deguchi, N. Takeshita, T.A. Balam, Y. Fujiyoshi and T. Takano-Yamamoto*

Department of Orthodontics, Okayama University Graduate School of Medicine and Dentistry, 2-5-1, Shikata-cho, Okayama, 700, Japan;

Correspondence: * corresponding author, t_yamamo{at}md.okayama-u.ac.jp

Neuropeptides have been suggested to play a role in pain transmission during orthodontic tooth movement. We examined this hypothesis by examining the effect of orthodontic tooth movement on the expression of galanin (GAL)-immunoreactive (ir) nerve fibers in the periodontal ligament (PDL) of one mesial root (MR) and two distal roots (DRs) of the rat maxillary first molar. In control rats, GAL-ir fibers were very rare in the PDL. One day after the insertion of the elastic band, the number of GAL-ir fibers increased, becoming most numerous at 3 days. From 5 to 28 days, GAL-ir fibers tended to decrease. Electron microscopic observation showed that all of the GAL-ir fibers were unmyelinated. These findings suggest that GAL-containing nerve fibers in the PDL may play an important role in the response of the tissue to experimental tooth movement.

Key Words: galanin • tooth movement • periodontal ligament • rat

Journal of Dental Research, Vol. 82, No. 9, 677-681 (2003)
DOI: 10.1177/154405910308200904
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