This Article Figures Only Free Full Text Free Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Szpaderska, A.M. Articles by DiPietro, L.A. Search for Related Content PubMed PubMed Citation Articles by Szpaderska, A.M. Articles by DiPietro, L.A. Social Bookmarking                         What's this?

Differential Injury Responses in Oral Mucosal and Cutaneous Wounds

Burn and Shock Trauma Institute, Department of Surgery, Loyola University Medical Center, 2160 S. First Ave., Maywood, IL 60153;

Correspondence: ^* corresponding author, ldipiet{at}lumc.edu

Oral mucosa heals faster than does skin, yet few studies have compared the repair at oral mucosal and cutaneous sites. To determine whether the privileged healing of oral injuries involves a differential inflammatory phase, we compared the inflammatory cell infiltrate and cytokine production in wounds of equivalent size in oral mucosa and skin. Significantly lower levels of macrophage, neutrophil, and T-cell infiltration were observed in oral vs. dermal wounds. RT-PCR analysis of inflammatory cytokine production demonstrated that oral wounds contained significantly less IL-6 and KC than did skin wounds. Similarly, the level of the pro-fibrotic cytokine TGF-b1 was lower in mucosal than in skin wounds. No significant differences between skin and mucosal wounds were observed for the expression of the anti-inflammatory cytokine IL-10 and the TGF-β1 modulators, fibromodulin and LTBP-1. These findings demonstrate that diminished inflammation is a key feature of the privileged repair of oral mucosa.

Key Words: wound healing • inflammation • mucosa • skin

Journal of Dental Research, Vol. 82, No. 8, 621-626 (2003)
DOI: 10.1177/154405910308200810


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				R. G. Jansen, T. H. van Kuppevelt, W. F. Daamen, A. M. Kuijpers-Jagtman, and J. W. Von den Hoff Interferon-{gamma}-loaded collagen scaffolds reduce myofibroblast numbers in rat palatal mucosa Eur J Orthod, January 27, 2010; (2010): cjp129v1 - cjp129. [Abstract] [Full Text] [PDF]

				A. Lin, A. Hokugo, J. Choi, and I. Nishimura Small Cytoskeleton-Associated Molecule, Fibroblast Growth Factor Receptor 1 Oncogene Partner 2/Wound Inducible Transcript-3.0 (FGFR1OP2/wit3.0), Facilitates Fibroblast-Driven Wound Closure Am. J. Pathol., January 1, 2010; 176(1): 108 - 121. [Abstract] [Full Text] [PDF]

				M. J. Oudhoff, K. L. Kroeze, K. Nazmi, P. A. M. van den Keijbus, W. van 't Hof, M. Fernandez-Borja, P. L. Hordijk, S. Gibbs, J. G. M. Bolscher, and E. C. I. Veerman Structure-activity analysis of histatin, a potent wound healing peptide from human saliva: cyclization of histatin potentiates molar activity 1000-fold FASEB J, November 1, 2009; 23(11): 3928 - 3935. [Abstract] [Full Text] [PDF]

				S. Enoch, I. Wall, M. Peake, L. Davies, J. Farrier, P. Giles, D. Baird, D. Kipling, P. Price, R. Moseley, et al. Increased Oral Fibroblast Lifespan Is Telomerase-independent Journal of Dental Research, October 1, 2009; 88(10): 916 - 921. [Abstract] [Full Text] [PDF]

				A. Eslami, C. L. Gallant-Behm, D. A. Hart, C. Wiebe, D. Honardoust, H. Gardner, L. Hakkinen, and H. S. Larjava Expression of Integrin {alpha}v{beta}6 and TGF-{beta} in Scarless vs Scar-forming Wound Healing J. Histochem. Cytochem., June 1, 2009; 57(6): 543 - 557. [Abstract] [Full Text] [PDF]

				T. J. Kaitu'u-Lino, D. J. Phillips, N. B. Morison, and L. A. Salamonsen A New Role for Activin in Endometrial Repair after Menses Endocrinology, April 1, 2009; 150(4): 1904 - 1911. [Abstract] [Full Text] [PDF]

				S. Meran, D. W. Thomas, P. Stephens, S. Enoch, J. Martin, R. Steadman, and A. O. Phillips Hyaluronan Facilitates Transforming Growth Factor-{beta}1-mediated Fibroblast Proliferation J. Biol. Chem., March 7, 2008; 283(10): 6530 - 6545. [Abstract] [Full Text] [PDF]

				K. Gronert Lipid Autacoids in Inflammation and Injury Responses: A Matter of Privilege Mol. Interv., February 1, 2008; 8(1): 28 - 35. [Abstract] [Full Text] [PDF]

				J. A. Bosch, C. G. Engeland, J. T. Cacioppo, and P. T. Marucha Depressive Symptoms Predict Mucosal Wound Healing Psychosom Med, September 1, 2007; 69(7): 597 - 605. [Abstract] [Full Text] [PDF]

				S. Meran, D. Thomas, P. Stephens, J. Martin, T. Bowen, A. Phillips, and R. Steadman Involvement of Hyaluronan in Regulation of Fibroblast Phenotype J. Biol. Chem., August 31, 2007; 282(35): 25687 - 25697. [Abstract] [Full Text] [PDF]

				M. K. Inder, N. Ueda, A. A. Mercer, S. B. Fleming, and L. M. Wise Bovine papular stomatitis virus encodes a functionally distinct VEGF that binds both VEGFR-1 and VEGFR-2 J. Gen. Virol., March 1, 2007; 88(3): 781 - 791. [Abstract] [Full Text] [PDF]

				C. G. Engeland, J. A. Bosch, J. T. Cacioppo, and P. T. Marucha Mucosal Wound Healing: The Roles of Age and Sex Arch Surg, December 1, 2006; 141(12): 1193 - 1197. [Abstract] [Full Text] [PDF]

				M. J. Velardo, C. Burger, P. R. Williams, H. V. Baker, M. C. Lopez, T. H. Mareci, T. E. White, N. Muzyczka, and P. J. Reier Patterns of Gene Expression Reveal a Temporally Orchestrated Wound Healing Response in the Injured Spinal Cord J. Neurosci., September 29, 2004; 24(39): 8562 - 8576. [Abstract] [Full Text] [PDF]

				C. Sukotjo, A. Lin, K. Song, T. Ogawa, B. Wu, and I. Nishimura Oral Fibroblast Expression of wound-inducible transcript 3.0 (wit3.0) Accelerates the Collagen Gel Contraction in Vitro J. Biol. Chem., December 19, 2003; 278(51): 51527 - 51534. [Abstract] [Full Text] [PDF]