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Journal of Dental Research
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Clinical

Single-nucleotide Polymorphism in the CD14 Promoter and Periodontal Disease Expression in a Japanese Population

K. Yamazaki*,1, K. Ueki-Maruyama1, T. Oda1, K. Tabeta1, Y. Shimada1, H. Tai1, T. Nakajima1, H. Yoshie1, D. Herawati2 and G.J. Seymour3

1 Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, 5274, Gakkocho-Dori 2-ban-cho, Niigata 951-8514, Japan;
3 Oral Biology and Pathology, Department of Dentistry, The University of Queensland, Brisbane, Australia;

Correspondence: * corresponding author, kaz{at}dent.niigata-u.ac.jp

It has been reported that there is a relationship between a single-nucleotide polymorphism (SNP) in the promoter region of the CD14 gene at position -159 (C->T) and infectious diseases. The aim of the present study was to test the hypthesis that expression of this SNP correlates with periodontal disease in a Japanese population. The CD14 genotype was determined in 163 subjects with periodontitis and in 104 age- and gender-matched control subjects without periodontitis. The genotype distribution and allele frequency within the periodontitis patients were not significantly different from those of control subjects. There was, however, a significant difference in the genotype distribution between young patients (< 35 yrs) and older patients (≥ 35 yrs). These findings suggest that CD14 -159C/T polymorphism is not related to the development of periodontitis in a Japanese population, but that, within the periodontitis subjects, expression of the SNP may be related to early disease activity.

Key Words: CD14 • polymorphism • chronic periodontitis • Japanese

Journal of Dental Research, Vol. 82, No. 8, 612-616 (2003)
DOI: 10.1177/154405910308200808
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