Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Free Full Text Free
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Carinci, F.
Right arrow Articles by Volinia, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carinci, F.
Right arrow Articles by Volinia, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biological

Genetic Expression Profiling of Six Odontogenic Tumors

F. Carinci1, F. Francioso2, A. Piattelli3, C. Rubini4, M. Fioroni3, R. Evangelisti2,5,*, D. Arcelli2, L. Tosi6, F. Pezzetti7, P. Carinci6 and S. Volinia2,8

1 Department of Maxillofacial Surgery, University of Ferrara;
2 Department of Morphology and Embryology, University of Ferrara, Via Fossato di Mortara 64/b, 44100 Ferrara, Italy;
3 Dental Clinic, University of Chieti;
4 Department of Pathology, University of Ancona;
5 Histology, University of Ferrara;
6 Institute of Histology and Centre of Molecular Genetic, CARISBO Foundation, University of Bologna;
7 Institute of Histology and General Embryology, University of Bologna; and
8 TIGEM-Telethon Institute of Genetics and Medicine, Via P. Castellino, Napoli;

Correspondence: *corresponding author, enr{at}unife.it

Odontogenic tumors are rare neoplasms arising from the odontogenic apparatus. We aimed to identify molecular characteristics associated with odontogenic tumorigenesis and malignancy. To this end, we investigated the expression level of human genes by using, for the first time in odontogenic tumors, the technique of expression profiling. Gene expression alterations common to all six odontogenic tumors were identified by the use of cDNA microarrays containing 19,000 human cDNAs. Statistical analysis on a subset of 4974 cDNAs present in the biopsies identified 506 distinct genes associated with the tumors (p-value < 0.01). Gene ontology analysis of the cellular processes which were differentially regulated in odontogenic tumors was accomplished by the use of a subset of 1409 annotated genes. Finally, 43 cDNAs differentiated the three malignant odontogenic tumors (ameloblastic carcinoma, clear cell odontogenic tumor, granular cell odontogenic tumor) from the three benign ameloblastoma biopsies (p < 0.01). The identified genes might help us better classify borderline odontogenic tumors.

Key Words: expression profiling • DNA microarray • odontogenic tumors

Journal of Dental Research, Vol. 82, No. 7, 551-557 (2003)
DOI: 10.1177/154405910308200713
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Histochem. Cytochem.Home page
B. Ruhin-Poncet, S. Ghoul-Mazgar, D. Hotton, F. Capron, M. H. Jaafoura, G. Goubin, and A. Berdal
Msx and Dlx Homeogene Expression in Epithelial Odontogenic Tumors
J. Histochem. Cytochem., January 1, 2009; 57(1): 69 - 78.
[Abstract] [Full Text] [PDF]