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Journal of Dental Research
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Clinical

Segregation Analysis of Mandibular Prognathism in Libya

A.A. El-Gheriani1,2, B.S. Maher2, A.S. El-Gheriani3, J.J. Sciote4, F.A. Abu-shahba5, R. Al-Azemi4,7 and M.L. Marazita1,2,6,*

1 Department of Human Genetics, Graduate School of Public Health, 500 Cellomics Bldg., University of Pittsburgh, 100 Technology Dr., Pittsburgh, PA 15219;
2 Center for Craniofacial and Dental Genetics, Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, PA;
3 Department of Prosthodontics, Faculty of Dentistry, Benghazi, Libya (currently Department of Restorative Dentistry, Ajman University of Science and Technology, Ajman, UAE);
4 Department of Orthodontics, School of Dental Medicine, University of Pittsburgh, PA
7 (currently Department of Orthodontics, Ministry of Health, Kuwait);
5 Department of Orthodontics, Faculty of Dentistry, Benghazi, Libya; and
6 Department of Oral and Maxillofacial Surgery, School of Dental Medicine, University of Pittsburgh, PA;

Correspondence: *corresponding author, marazita{at}sdmgenetics.pitt.edu

The etiology of mandibular prognathism has been attributed to various genetic inheritance patterns and some environmental factors. The variation in inheritance patterns can be partly due to the use of different statistical approaches in the respective studies. The objective of this study was to investigate the role of genetic influences in the etiology of this trait. We performed segregation analysis on 37 families of patients currently being treated for mandibular prognathism. Mandibular prognathism was treated as a qualitative trait, with cephalometric radiographs, dental models, and photographs used to verify diagnosis. Segregation analysis of a prognathic mandible in the entire dataset supported a transmissible Mendelian major effect, with a dominant mode of inheritance determined to be the most parsimonious.

Key Words: mandible • mandibular prognathism • Class III malocclusion • genetics

Journal of Dental Research, Vol. 82, No. 7, 523-527 (2003)
DOI: 10.1177/154405910308200707
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