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Journal of Dental Research
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Biological

Dentin-induced in vivo Inflammatory Response and in vitro Activation of Murine Macrophages

V.S. Lara1,*, F. Figueiredo2, T.A. da Silva1 and F.Q. Cunha3

1 Department of Stomatology, Pathology, Bauru Dental School, University of São Paulo-Bauru, Rua Sérvio Túlio Carrijo Coube, 3-33, Apto 91-C, Jardim Infante Dom Henrique, 17012-632-Bauru, São Paulo, Brazil;
2 Catholic University of Brasília and Brasília Medicine School, University of Brasília-Brasília, Distrito Federal, Brazil; and
3 Department of Pharmacology, Ribeirão Preto Medicine School, University of São Paulo-Ribeirão Preto, São Paulo, Brazil;

Correspondence: *corresponding author, vanessa{at}fob.usp.br

The activation of inflammatory cells and consequent release of mediators play an important role in the resorption of mineralized tissues. In the present study, we examined the ability of dentin extracts to induce inflammatory cell recruitment and activation. We showed here that dentin extracts triggered an intense cell migration and progressive cell maturation, in a time- and dose-dependent manner. Expression of interleukin-1β (IL-1β), tumor necrosis factor-{alpha} (TNF-{alpha}), nitric oxide (NO), and hydrogen peroxide (H2O2) was also up-regulated by dentin extracts. These results show that inflammatory events can be elicited in response to dentin, which may suggest a possible involvement of dentin molecules in the inflammatory events, coupled with their release at the root resorption sites.

Key Words: root resorption • nitric oxide • cytokines • dentin

Journal of Dental Research, Vol. 82, No. 6, 460-465 (2003)
DOI: 10.1177/154405910308200611
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