|
Sign In to gain access to subscriptions and/or personal tools.
|
Retention in Plaque and Remineralization of Enamel Lesions by Various Forms of Calcium in a Mouthrinse or Sugar-free Chewing Gum
E.C. Reynolds*,
F. Cai,
P. Shen and
G.D. Walker
School of Dental Science, The University of Melbourne, 711 Elizabeth Street, Melbourne, Victoria, 3000, Australia;
Correspondence: *corresponding author, e.reynolds{at}unimelb.edu.au
Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) nanocomplexes incorporated into sugar-free chewing gum have been shown to remineralize enamel subsurface lesions in situ. The aim of this study was to compare the ability of CPP-ACP, with that of other forms of calcium, to be retained in supragingival plaque and remineralize enamel subsurface lesions in situ when delivered in a mouthrinse or sugar-free gum in randomized, double-blind trials. In the mouthrinse study, only the CPP-ACP-containing mouthrinse significantly increased plaque calcium and inorganic phosphate levels, and the CPP were immunolocalized to the surfaces of bacterial cells as well as the intercellular matrix. In the chewing gum studies, the gum containing the CPP-ACP, although not containing the most calcium per piece of gum, produced the highest level of enamel remineralization independent of gum-chewing frequency and duration. The CPP could be detected in plaque extracts 3 hrs after subjects chewed the CPP-ACP-containing gum. The results showed that CPP-ACP were superior to other forms of calcium in remineralizing enamel subsurface lesions.
Key Words: casein phosphopeptide-amorphous calcium phosphate • dental plaque • incorporation • mouthrinse • sugar-free chewing gum • enamel remineralization
Journal of Dental Research, Vol. 82, No. 3,
206-211 (2003)
DOI: 10.1177/154405910308200311
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
D.L. Bailey, G.G. Adams, C.E. Tsao, A. Hyslop, K. Escobar, D. J. Manton, E.C. Reynolds, and M.V. Morgan
Regression of Post-orthodontic Lesions by a Remineralizing Cream
Journal of Dental Research,
December 1, 2009;
88(12):
1148 - 1153.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E.C. Reynolds
Casein Phosphopeptide-Amorphous Calcium Phosphate: The Scientific Evidence
Advances in Dental Research,
August 1, 2009;
21(1):
25 - 29.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D.T. Zero
RecaldentTM--Evidence for Clinical Activity
Advances in Dental Research,
August 1, 2009;
21(1):
30 - 34.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Panich and S. Poolthong
The Effect of Casein Phosphopeptide-amorphous Calcium Phosphate and a Cola Soft Drink on In Vitro Enamel Hardness
J Am Dent Assoc,
April 1, 2009;
140(4):
455 - 460.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Azarpazhooh and H. Limeback
Clinical Efficacy of Casein Derivatives: A Systematic Review of the Literature
J Am Dent Assoc,
July 1, 2008;
139(7):
915 - 924.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Garcia-Godoy and M. J. Hicks
Maintaining the integrity of the enamel surface: The role of dental biofilm, saliva and preventive agents in enamel demineralization and remineralization
J Am Dent Assoc,
May 1, 2008;
139(suppl_2):
25S - 34S.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Cross, N. L. Huq, J. E. Palamara, J. W. Perich, and E. C. Reynolds
Physicochemical Characterization of Casein Phosphopeptide-Amorphous Calcium Phosphate Nanocomplexes
J. Biol. Chem.,
April 15, 2005;
280(15):
15362 - 15369.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
