Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Gilthorpe, M.S.
Right arrow Articles by Johnson, N.W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gilthorpe, M.S.
Right arrow Articles by Johnson, N.W.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Clinical

Unification of the "Burst" and "Linear" Theories of Periodontal Disease Progression: A Multilevel Manifestation of the Same Phenomenon

M.S. Gilthorpe1,*, A.T. Zamzuri2, G.S. Griffiths3, I.H. Maddick4, K.A. Eaton3 and N.W. Johnson5

1 Biostatistics Unit, Academic Unit of Epidemiology and Health Services Research, Medical School, University of Leeds, 24 Hyde Terrace, Leeds, LS2 9LN, UK;
2 Dental Training School Malaysia, No 3 Sepoy Lines Road, 10450 Penang, Malaysia;
3 Department of Periodontology &
4 Department of Paediatric Dentistry, Eastman Dental Institute, University College London, 256 Gray’s Inn Road, London, UK; and
5 Department of Oral and Maxillofacial Medicine and Pathology, Guy’s King’s and St Thomas’ Schools of Medicine, Dentistry and Biomedical Sciences, Caldecot Rd, London, UK;

Correspondence: *corresponding author, m.s.gilthorpe{at}leeds.ac.uk

Previously, burst and linear theories for periodontal disease progression were proposed based on different but limited statistical methods of analysis. Multilevel modeling provides a new approach, yielding a more comprehensive model. Random coefficient models were used to analyze longitudinal periodontal data consisting of repeated measures (level 1), sites (level 2), teeth (level 3), and subjects (level 4). Large negative and highly significant correlations between random linear and quadratic time coefficients indicated that subjects and teeth with greater-than-average linear change experienced decelerated variation. Conversely, subjects and teeth with less-than-average linear change experienced accelerated variation. Change therefore exhibited a dynamic regression to the mean at the tooth and subject levels. Since no equilibrium was attained throughout the study, changes were cyclical. When considered as a multilevel system, the "linear" and "burst" theories of periodontal disease progression are a manifestation of the same phenomenon: Some sites improve while others progress, in a cyclical manner.

Key Words: multilevel modeling • hierarchical linear modeling • random coefficients • lifetime cumulative attachment loss • pocket probing depth

Journal of Dental Research, Vol. 82, No. 3, 200-205 (2003)
DOI: 10.1177/154405910308200310
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JAMAHome page
W. M. Thomson, R. Poulton, J. M. Broadbent, T. E. Moffitt, A. Caspi, J. D. Beck, D. Welch, and R. J. Hancox
Cannabis Smoking and Periodontal Disease Among Young Adults
JAMA, February 6, 2008; 299(5): 525 - 531.
[Abstract] [Full Text] [PDF]

Home page
 Stat Methods Med ResHome page
A. Blance, Y.-K. Tu, and M. S Gilthorpe
A multilevel modelling solution to mathematical coupling
Statistical Methods in Medical Research, December 1, 2005; 14(6): 553 - 565.
[Abstract] [PDF]