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Journal of Dental Research
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Biological

Expression of Vascular Endothelial Growth Factor and the Effects on Bone Remodeling during Experimental Tooth Movement

S. Kohno, M. Kaku*, K. Tsutsui, M. Motokawa, J. Ohtani, K. Tenjo, Y. Tohma, C. Tokimasa, T. Fujita, T. Kawata and K. Tanne

Department of Orthodontics, Hiroshima University Faculty of Dentistry, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan;

Correspondence: *corresponding author, mkaku{at}hiroshima-u.ac.jp

Vascular endothelial growth factor (VEGF) has an ability to induce functional osteoclasts as well as neovascularization. We recently reported that the number of osteoclasts was enhanced by the injection of recombinant human VEGF (rhVEGF) with the application of mechanical force for experimental tooth movement. In this study, the expression of VEGF was detected in osteoblasts on the tension side of the alveolar bone. Moreover, the rate of tooth movement was significantly increased in the rhVEGF injection groups compared with the controls. These results suggested that VEGF, highly expressed by mechanical stimuli, enhances the number of osteoclasts as a paracrine factor, and that the amount of tooth movement is accelerated by both endogenous VEGF and injected rhVEGF.

Key Words: VEGF • osteoclast • osteoblast • bone remodeling • experimental tooth movement

Journal of Dental Research, Vol. 82, No. 3, 177-182 (2003)
DOI: 10.1177/154405910308200306
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A. Miyagawa, M. Chiba, H. Hayashi, and K. Igarashi
Compressive Force Induces VEGF Production in Periodontal Tissues
Journal of Dental Research, August 1, 2009; 88(8): 752 - 756.
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