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Rabbit Calvarial Wound Healing by Means of Seeded Caprotite^® Scaffolds

¹ Plastic Surgery, University of Pittsburgh;
² Plastic surgery, University of California-Irvine;
³ Complex Engineered Systems, Carnegie Mellon University, Pittsburgh, PA;
⁴ Biomedical Health Engineering and Biological Sciences, and Bone Tissue Engineering Center, Carnegie Mellon University, Pittsburgh, PA;
⁵ Oral Medicine and Pathology, 329 Salk Hall, University of Pittsburgh, Pittsburgh, PA, USA, 15261;
⁶ Radiology, University of Pittsburgh;
⁷ Orthopaedic Surgery, University of Pittsburgh;
⁸ The Robotics Institute, Carnegie Mellon University, Pittsburgh, PA; and
⁹ Anthropology and Orthodontics, University of Pittsburgh;

Correspondence: *corresponding author, mpm4{at}pitt.edu

Autologous bone is the most successful bone-grafting material; however, limited supply and donor site morbidity are problematic. Synthetic bone substitutes are effective, but healing is slow and unpredictable. Osseous wound healing may be enhanced if bone substitutes are combined with autologous bone marrow cells. To test this hypothesis, we created 40 calvarial defects in 20 12-week-old New Zealand White rabbits, divided into four groups: (1) unrepaired controls, (2) autologous bone grafts, (3) unseeded Caprotite^® (a polymer-ceramic composite) grafts, and (4) Caprotite^® grafts seeded with autologous bone marrow stromal cells. CT scans were obtained at 0, 6, and 12 weeks post-operatively, and defects were harvested for histology. Defects repaired with autologous bone had significantly (p < 0.05) more bone than the other three groups, although seeded Caprotite^® defects showed different wound-healing sequelae. Results suggest that seeded Caprotite^® scaffolds did not significantly enhance osseous defect healing compared with controls.

Key Words: Caprotite^® • calvaria • rabbits • scaffolds • bone cells

Journal of Dental Research, Vol. 82, No. 2, 131-135 (2003)
DOI: 10.1177/154405910308200211


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