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Journal of Dental Research
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Clinical

Relationship of Periodontal Disease and Edentulism to Stroke/TIA

J.R. Elter1,*, S. Offenbacher1, J.F. Toole2 and J.D. Beck1

1 School of Dentistry, CB#7450, University of North Carolina, Chapel Hill, NC 27599-7450, USA; and
2 Wake Forest University Bowman Gray School of Medicine;

Correspondence: *corresponding author, john_elter{at}unc.edu

Periodontitis has been shown to increase the systemic inflammatory response, which has been implicated in atherosclerosis and cerebrovascular events. We hypothesized an association between periodontitis or edentulism and Stroke/TIA in the ARIC Study. Data on 9415 dentate and 1491 edentulous adults included demographics, cardiovascular outcomes, lifestyle, laboratory measures, and, for 6436 of the dentate, a dental examination. The dependent variable was Stroke/TIA, and the exposure was extent (%) of attachment level 3+ millimeters (AL). Quartiles of AL and edentulism were compared for Stroke/TIA using odds ratios (OR) and 95% confidence intervals (CI), and confounders were controlled by logistic regression. Stroke/TIA was prevalent in 13.5% of periodontal examinees, 15.6% of dentate non-examinees, and 22.5% of edentulous persons. The highest quartile of AL (OR 1.3, CI 1.02-1.7) and edentulism (OR 1.4, CI 1.5-2.0) were associated with Stroke/TIA.

Key Words: periodontal diseases • edentulism • stroke • transient ischemic attack • epidemiology

Journal of Dental Research, Vol. 82, No. 12, 998-1001 (2003)
DOI: 10.1177/154405910308201212
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