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Journal of Dental Research
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*Substance via MeSH
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*2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN
*OCTACHLORODIBENZO-P-DIOXIN
*POLYCHLORINATED BIPHENYLS
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Clinical

Detectable Dioxins in Human Saliva and Their Effects on Gingival Epithelial Cells

T. Ogawa1,*, Y. Asai1, M. Yamashita2 and T. Takasuga2

1 Department of Oral Microbiology, Asahi University School of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan; and
2 Shimadzu Techno-Research, Inc., 1 Shimoai-cho, Nishinokyo, Nakagyo-ku, Kyoto 604-8436, Japan;

Correspondence: *corresponding author, tomo527{at}dent.asahi-u.ac.jp

Dioxin, a powerful hormone-disrupting chemical, exhibits serious health effects when it reaches body fat. Here we analyzed coplanar polychlorinated biphenyls (PCBs) and polychlorinated-dibenzo-p-dioxins (PCDDs) in human saliva as compared with blood specimens, and examined their effects on human gingival epithelial cells (HGEC). High levels of tri- and tetrachlorinated PCBs were found in saliva, whereas we detected predominantly hexa- and heptachlorinated PCBs in blood. Among PCDDs, the saliva and blood specimens contained mainly 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin (OCDD). Among the toxic dioxins proposed by the World Health Organization (WHO) in 1998, 2,3',4,4',5-pentachlorobiphenyl (PCB 118) and OCDD, which were mainly found in saliva, significantly induced IL-8 production in HGEC. Furthermore, these two dioxins markedly augmented IL-8 production stimulated with fimbriae from Porphyromonas gingivalis, which is well-known as a pathogenic factor in periodontal diseases. These results suggest that dioxins in saliva may be a risk factor for periodontal diseases.

Key Words: dioxins • coplanar polychlorinated biphenyls • saliva • human gingival epithelial cells • aryl hydrocarbon receptor

Journal of Dental Research, Vol. 82, No. 10, 849-853 (2003)
DOI: 10.1177/154405910308201017
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