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Journal of Dental Research
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CONCISE REVIEW

Gene Therapy for the Treatment of Oral Squamous Cell Carcinoma

S. Xi1 and J.R. Grandis1,2

1 Departments of Otolaryngology and
2 Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;

Correspondence: *corresponding author, The Eye and Ear Institute, Suite 500, 200 Lothrop Street, Pittsburgh, PA 15213, jgrandis{at}pitt.edu

Despite advances in surgery, radiotherapy, and chemotherapy, the survival of patients with oral squamous cell carcinoma has not significantly improved over the past several decades. Treatment options for recurrent or refractory oral cancers are limited. Gene therapy for oral cancer is currently under investigation in clinical trials. The goal of cancer gene therapy is to introduce new genetic material into target cells without toxicity to non-target tissues. This review discusses the techniques used in cancer gene therapy for oral squamous cell carcinoma and summarizes the ongoing strategies that are being evaluated in clinical trials.

Key Words: gene therapy • oral cancer • oral squamous cell carcinoma

Journal of Dental Research, Vol. 82, No. 1, 11-16 (2003)
DOI: 10.1177/154405910308200104
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