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Journal of Dental Research
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Biological

The Localization of Matrix Metalloproteinase-20 (MMP-20, Enamelysin) in Mature Human Teeth

M. Sulkala1, M. Larmas1,2, T. Sorsa3, T. Salo1,5,* and L. Tjäderhane4,*

1 Institute of Dentistry, University of Oulu, PO Box 5281, FIN-90014 University of Oulu, Finland;
2 Oulu University Hospital, Oulu, Finland;
3 Oral Pathology Unit and Biomedicum Laboratory Diagnostics (HUCH), University of Helsinki, Helsinki, Finland; and
4 Faculty of Dentistry, University of Toronto, Toronto, ON, Canada;

Correspondence: 5 corresponding author, Tuula.Salo{at}oulu.fi;

MMP-20 (enamelysin), the matrix metalloproteinase family member discovered in the enamel organ, has also been detected in odontoblasts during dentin formation. We studied the presence and localization of MMP-20 in mature human teeth in health and disease. In immunohistochemistry, MMP-20-positive staining was observed most intensively in the radicular odontoblastic layer and also in dilated dentinal tubuli of caries lesions. By Western blotting, MMP-20 was detected in odontoblasts and pulp tissue of both sound and carious teeth, in dentinal fluid and dentin of sound teeth, but not in soft carious dentin. We conclude that MMP-20 produced during primary dentinogenesis is incorporated into dentin and may be released during caries progression. The main cellular source of MMP-20 in the dentin-pulp complex is the odontoblasts, which secrete MMP-20 into the dentinal fluid.

Key Words: MMP-20 • dentin • dentinal fluid • caries

Journal of Dental Research, Vol. 81, No. 9, 603-607 (2002)
DOI: 10.1177/154405910208100905
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