This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Pekkala, E. Articles by Larmas, M. Search for Related Content PubMed PubMed Citation Articles by Pekkala, E. Articles by Larmas, M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS CALCIUM, ELEMENTAL PHOSPHORUS POTASSIUM SODIUM Social Bookmarking                         What's this?

The Effect of a High-sucrose Diet on Dentin Formation and Dental Caries in Hyperinsulinemic Rats

¹ Institute of Dentistry, PO Box 5281, FIN-90014 University of Oulu, Finland;
² Oulu University Hospital, Oulu, Finland;
³ Laboratory, Oulu University Hospital;
⁴ Oulu Municipal Health Centre, Oulu, Finland; and
⁵ Department of Endodontics, Faculty of Dentistry, University of Toronto, ON, Canada;

Correspondence: ^* corresponding author, liisa.valikangas{at}oulu.fi

A high-sucrose diet decreases dentin formation and its minerals, but the mechanisms behind the effect are largely unknown. We studied the combined and separate effects of sucrose and insulin on dentin formation and mineral metabolism in growing rats. At weaning, animals were randomized into 4 groups: control/sucrose diets both with and without external insulin (1 U/x 100 g body weight daily). After 4 weeks, we measured areas of dentin formation, numbers and areas of dentinal caries lesions, and serum and urine glucose, insulin, Ca, Na, K, and P. Exogenous insulin increased serum and urine insulin levels and decreased serum glucose level, but did not affect dentin formation or dentinal caries lesion formation or progression. A high-sucrose diet decreased dentin formation independently of insulin. The differences in serum and urine minerals between the groups were minor. The findings confirm that sucrose-diet-induced reduction in dentinogenesis is independent of insulin and loss of minerals in urine.

Key Words: dentin formation • sucrose • insulin • mineral excretion • rat

Journal of Dental Research, Vol. 81, No. 8, 536-540 (2002)
DOI: 10.1177/154405910208100807


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?