Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Välimaa, H.
Right arrow Articles by Tenovuo, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Välimaa, H.
Right arrow Articles by Tenovuo, J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Clinical

Salivary Defense Factors in Herpes Simplex Virus Infection

H. Välimaa1,2,*, M. Waris3, V. Hukkanen2, M.F.J. Blankenvoorde4,5, A.V. Nieuw Amerongen4 and J. Tenovuo1

1 Department of Cariology, Institute of Dentistry,
2 Department of Virology,
3 Laboratory of Biophysics, Institute of Biomedicine, University of Turku, Turku, Finland;
4 Department of Oral Biochemistry, ACTA, Amsterdam, the Netherlands; and
5 currently at Aventis Pharma, Medical Department, Hoevelaken, the Netherlands;

Correspondence: *corresponding author, hannamari.valimaa{at}utu.fi

Saliva may contribute to a lowering of the infectious herpes simplex virus (HSV) dose during transmission and consequently abrogate infection or lead to decreased reactivation. To test this hypothesis, we assayed saliva for innate defense factors, immunoglobulin content, and the capacity to interfere with HSV infection. Serum or salivary anti-HSV IgG levels did not correlate with control of recurrent labial herpes (RLH) and were significantly higher in subjects with RLH compared with asymptomatic seropositive subjects. Although no differences in levels or output rate of innate defense factors between the groups were observed, the salivary neutralizing activity correlated with lactoferrin and hypothiocyanite concentrations in the asymptomatic seropositive group. Our results suggest that saliva contains factors, in addition to anti-HSV immunoglobulins, that neutralize HSV and may indirectly contribute to the control of RLH.

Key Words: saliva • defense • innate • HSV

Journal of Dental Research, Vol. 81, No. 6, 416-421 (2002)
DOI: 10.1177/154405910208100612
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Gen. Virol.Home page
P. Peri, V. Hukkanen, K. Nuutila, P. Saukko, M. Abrahamson, and T. Vuorinen
The cysteine protease inhibitors cystatins inhibit herpes simplex virus type 1-induced apoptosis and virus yield in HEp-2 cells
J. Gen. Virol., August 1, 2007; 88(8): 2101 - 2105.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. E. Kaufman, A. M. Azcuy, E. D. Varnell, G. D. Sloop, H. W. Thompson, and J. M. Hill
HSV-1 DNA in Tears and Saliva of Normal Adults
Invest. Ophthalmol. Vis. Sci., January 1, 2005; 46(1): 241 - 247.
[Abstract] [Full Text] [PDF]