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Journal of Dental Research
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Biological

Interferon-gamma Deficiency Attenuates Local P. gingivalis-induced Inflammation

Y. Houri-Haddad1, W.A. Soskolne1, E. Shai2, A. Palmon2 and L. Shapira1,*

1 Department of Periodontology and
2 Department of Oral Biology, Faculty of Dental Medicine, Hadassah and Hebrew University Medical Centers, PO Box 12272, Jerusalem 91120, Israel;

Correspondence: *corresponding author, shapiral{at}cc.huji.ac.il

Infection with the periodontal pathogen Porphyromonas gingivalis causes a strong local inflammatory reaction. Using IFN{gamma}-deficient mice, we tested the hypothesis that the absence of IFN{gamma} would result in a reduction of the local pro-inflammatory response to P. gingivalis. Cytokine secretion by macrophages from IFN{gamma}-/- animals was significantly attenuated. Addition of IFN{gamma} restored cytokine secretion. In vivo injection of P. gingivalis into subcutaneous chambers increased the intra-chamber leukocyte counts and TNF{alpha} and IL-1β levels. This increase was significantly lower in the IFN{gamma}-/- mice. Local reconstitution of IFN{gamma}-/- mice at the site of inflammation with the IFN{gamma} gene increased the levels of TNF{alpha} and decreased the IL-10 levels. Anti-P. gingivalis IgG1 levels, a marker of Th2 response, were higher in immunized IFN{gamma}-/- than in IFN{gamma}+/+ mice. The results suggest that lack of IFN{gamma} reduced the amplitude of the local pro-inflammatory response without decreasing the humoral protective response. The higher IgG1/IgG2a ratio observed supports the possibility of a Th2-dominant response in IFN{gamma}-deficient animals.

Key Words: IFN{gamma} deficiency • Porphyromonas gingivalis • inflammation • cytokines • antibody

Journal of Dental Research, Vol. 81, No. 6, 395-398 (2002)
DOI: 10.1177/154405910208100608
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