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Journal of Dental Research
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Biological

Parotid Gland Function and Dentin Apposition in Rat Molars

J. Leonora1,*,2, L. Tjäderhane3 and J.-M. Tieche1

1 Department of Physiology/Pharmacology, Risley Hall, and
2 Department of Internal Medicine, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA; and
3 Institute of Dentistry, University of Oulu, Oulu, Finland, and Department of Endodontics, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada;

Correspondence: *corresponding author, Jleonora{at}som.llu.edu

Previous studies have clearly established the down-regulating effect of a sucrose-rich diet on primary dentinogenesis in rat molars. Earlier observation of the negative effect of a high-sucrose diet on a parotid function involved in the control of intradentinal solute movement led us to hypothesize that parotid gland function(s) may have a role in regulating dentinogenesis. Dentin apposition in 1st and 2nd molars of young rats was measured by planimetry in sagittal sections. The following experimental variables were tested: standard and high-sucrose diets, removal of the parotid or the submandibular/sublingual glands, and diets in powder or pellet form. Removal of the submandibular/sublingual glands and changes in diet consistency did not significantly affect dentin apposition. Dentin apposition was significantly depressed by the high-sucrose diet or following parotidectomy. A further decrease followed the combination of the two treatments. Parotid glands appeared to exert a positive effect on dentin apposition in rat molars.

Key Words: dentinogenesis • parotid hormone • salivary function • odontoblasts

Journal of Dental Research, Vol. 81, No. 4, 259-264 (2002)
DOI: 10.1177/154405910208100407
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