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Journal of Dental Research
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Biological

Activation of Adenosine-receptor-enhanced iNOS mRNA Expression by Gingival Epithelial Cells

S. Murakami*, N. Yoshimura, H. Koide, J. Watanabe, M. Takedachi, M. Terakura, M. Yanagita, T. Hashikawa, T. Saho, Y. Shimabukuro and H. Okada

Department of Periodontology, Division of Oral Biology and Disease Control, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan;

Correspondence: *corresponding author, ipshinya{at}dent.osaka-u.ac.jp

A series of reports has revealed that adenosine has a plethora of biological actions toward a large variety of cells. In this study, we investigated the influence of adenosine receptor activation on iNOS mRNA expression in human gingival epithelial cells (HGEC) and SV-40-transformed HGEC. HGEC expressed adenosine receptor subtypes A1, A2a, and A2b, but not A3 mRNA. Ligation of adenosine receptors by a receptor agonist, 2-chloroadenosine (2CADO), enhanced iNOS mRNA expression by both HGEC and transformed HGEC. In addition, the adenosine receptor agonist enhanced the production of NO2-/NO3-, NO-derived stable end-products. An enhanced expression of iNOS mRNA and NO2-/NO3- was also observed when SV40-transformed HGEC were stimulated with CPA or CGS21680, A1- or A2a-selective adenosine receptor agonists, respectively. These results provide new evidence for the possible involvement of adenosine in the regulation of inflammatory responses by HGEC in periodontal tissues.

Key Words: periodontal disease • gingival epithelial cells • inflammation, adenosine • iNOS

Journal of Dental Research, Vol. 81, No. 4, 236-240 (2002)
DOI: 10.1177/154405910208100403
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