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Journal of Dental Research
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Clinical

β-Galactosidase Activity in Saliva is Associated with Oral Malodor

N. Sterer*, R. Bar-Ness Greenstein and M. Rosenberg

Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel-Aviv University, Ramat-Aviv, Israel, 69978;

Correspondence: *corresponding author, melros{at}post.tau.ac.il

Deglycosylation of oral mucins may be a critical initial step leading to their subsequent proteolysis and putrefaction. The present study was undertaken to determine whether activity in saliva of a major glycosidic enzyme (β–galactosidase) is associated with oral malodor in a group of 64 subjects. Enzyme activity was detected by the use of a chromogenic substrate (X-Gal) impregnated on paper discs. Malodor-related measurements included two odor judges' assessments of whole-mouth and tongue malodor, and volatile sulfide levels measured by a portable sulfide monitor (Interscan Corp.). β–galactosidase assay scores were significantly associated with both odor judges' scores for whole-mouth (p ≤ 0.002; Spearman) and tongue malodor (p ≤ 0.001; Spearman). β–galactosidase activity and sulfide monitor measurements both factored significantly into multiple regression equations for odor judge scores, yielding multiple r-values ranging from 0.47 (p = 0.0007) to 0.60 (p < 0.0001). Analysis of the data presented indicates that β–galactosidase activity in saliva is correlated with oral malodor.

Key Words: β-Galactosidase • oral malodor • diagnosis • glycoproteins • saliva

Journal of Dental Research, Vol. 81, No. 3, 182-185 (2002)
DOI: 10.1177/154405910208100308
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