Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Soell, M.
Right arrow Articles by Tenenbaum, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Soell, M.
Right arrow Articles by Tenenbaum, H.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Clinical

Cathepsin C, Matrix Metalloproteinases, and their Tissue Inhibitors in Gingiva and Gingival Crevicular Fluid from Periodontitis-affected Patients

M. Soell1, R. Elkaim2 and H. Tenenbaum1,*

1 Unité INSERM U 424, 11 rue Humann, 67085 Strasbourg CEDEX, France; and
2 Parogène, Strasbourg, France;

Correspondence: *corresponding author, h.tenenbaum{at}odonto3.u-strasbg.fr

Successive active phases observed in periodontal diseases may be explained either by a sudden activation of the pro-forms of tissue-stored degradative enzymes such as metalloproteinases (MMPs) or by an imbalance between metalloproteinases and their tissue inhibitors (TIMPs). To discriminate between these two hypotheses, we quantified the levels, the percentage of active form, and the activities of four metalloproteinases (MMPs -1, -2, -3, and -9), as well as the levels of two tissue inhibitors of metalloproteinases (TIMP-1 and -2) and the activity of cathepsin C in tissue extract supernatants and their corresponding gingival crevicular fluid samples collected from periodontitis-affected and healthy patients. Our results supported evidence that tissue destruction results from an imbalance of metalloproteinases over their tissue inhibitors rather than from a sudden activation of the pro-forms of these enzymes. A significant reduction in the activity of cathepsin C also contributed to the degradative process.

Key Words: cathepsin C • matrix metalloproteinases • tissue inhibitors of metalloproteinases • periodontitis

Journal of Dental Research, Vol. 81, No. 3, 174-178 (2002)
DOI: 10.1177/154405910208100306
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JDRHome page
V.D. La, A.B. Howell, and D. Grenier
Cranberry Proanthocyanidins Inhibit MMP Production and Activity
Journal of Dental Research, July 1, 2009; 88(7): 627 - 632.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Claudino, A. P. F. Trombone, C. R. Cardoso, S. B. Ferreira Jr, W. Martins Jr, G. F. Assis, C. F. Santos, P. C. Trevilatto, A. P. Campanelli, J. S. Silva, et al.
The broad effects of the functional IL-10 promoter-592 polymorphism: modulation of IL-10, TIMP-3, and OPG expression and their association with periodontal disease outcome
J. Leukoc. Biol., December 1, 2008; 84(6): 1565 - 1573.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
G. Kayaoglu and D. Orstavik
VIRULENCE FACTORS OF ENTEROCOCCUS FAECALIS: RELATIONSHIP TO ENDODONTIC DISEASE
Critical Reviews in Oral Biology & Medicine, September 1, 2004; 15(5): 308 - 320.
[Abstract] [Full Text] [PDF]