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Journal of Dental Research
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Clinical

A Clinical Evaluation of Implants in Irradiated Oral Cancer Patients

L.L. Visch*, M.A.J. van Waas, P.I.M. Schmitz1 and P.C. Levendag2

Department of Oral Function, Academic Center for Dentistry, Louwesweg 1, 1066EA Amsterdam, The Netherlands;
1 Department of Trials and Statistics, University Hospital Rotterdam-Daniel, Rotterdam, The Netherlands; and
2 Department of Radiation Oncology, University Hospital Rotterdam-Daniel, Rotterdam, The Netherlands;

Correspondence: *corresponding author, visch-implant{at}hetnet.nl

In this prospective study, we determined the effects of the time interval between irradiation and implant therapy, implant location, bone-resection surgery, and irradiation dose on implant survival. We analyzed the survival of 446 implants inserted after radiotherapy over a period of up to 14 years in 130 consecutive patients treated for oral cancer. The 10-year overall Kaplan-Meier implant survival percentage is 78%. The difference in survival percentages of implants inserted < 1 year and ≥ 1 year after irradiation (76% and 81%, respectively) is not significant. We concluded that implant survival is significantly influenced by the location (maxilla or mandible, 59% and 85%, respectively; p = 0.001), by the incidence of bone-resection surgery in the jaw where the implant was installed (p = 0.04), and by the irradiation dose at the implant site (< 50 Gray or ≥ 50 Gray, p = 0.05).

Key Words: dental implants • irradiation • osseointegration • prosthetic reconstruction • oral cancer

Journal of Dental Research, Vol. 81, No. 12, 856-859 (2002)
DOI: 10.1177/154405910208101212
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