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Journal of Dental Research
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Biomaterials & Bioengineering

Effect of Perfusion with Water on Demineralization of Human Dentin in vitro

A.R. Özok*, M.-K. Wu, J.M. ten Cate and P.R. Wesselink

Department of Cariology Endodontology Pedodontology, Academic Center for Dentistry Amsterdam (ACTA), Louwesweg 1, 1066 EA, Amsterdam, Netherlands;

Correspondence: * corresponding author, r.ozok{at}acta.nl

Dentinal fluid rarely features in caries studies of dentin. The mutual effects of in vitro perfusion and dentin demineralization were investigated. The correlation between the remaining dentin thickness and demineralization was also analyzed. Buccal cervical dentin windows in human tooth segments were demineralized either with or without perfusion with water at 3.14 kPa. Transverse microradiography revealed that dentin perfusion reduced the amount of mineral loss from the lesions by 22vol%; the reduction in lesion depth was 8%. Perfusion rate, which was measured throughout the demineralization process by means of a fluid transport model, did not change significantly. Lesions formed closer to the pulp exhibited increased mineral loss and lesion depth. In conclusion, dentinal fluid flow offers some protection against demineralization. For a better approximation of clinical reality, therefore, in vitro studies on dentinal caries should consider the effect of dentinal fluid flow.

Key Words: dentin demineralization • dentin perfusion • dentinal fluid • remaining dentin thickness

Journal of Dental Research, Vol. 81, No. 11, 733-737 (2002)
DOI: 10.1177/154405910208101102
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