Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Young, C.S.
Right arrow Articles by Yelick, P.C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Young, C.S.
Right arrow Articles by Yelick, P.C.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*LACTIC ACID
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biomaterials & Bioengineering

Tissue Engineering of Complex Tooth Structures on Biodegradable Polymer Scaffolds

C.S. Young1, S. Terada2, J.P. Vacanti2, M. Honda3, J.D. Bartlett1,* and P.C. Yelick1,*

1 Department of Cytokine Biology and Harvard-Forsyth Department of Oral Biology, The Forsyth Institute, Boston, MA 02115, USA;
2 Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; and
3 Department of Oral and Maxillofacial Surgery, Nagoya University School of Medicine, Nagoya, Japan;

Correspondence: * corresponding authors, pyelick{at}forsyth.org, jbartlett{at}forsyth.org

Tooth loss due to periodontal disease, dental caries, trauma, or a variety of genetic disorders continues to affect most adults adversely at some time in their lives. A biological tooth substitute that could replace lost teeth would provide a vital alternative to currently available clinical treatments. To pursue this goal, we dissociated porcine third molar tooth buds into single-cell suspensions and seeded them onto biodegradable polymers. After growing in rat hosts for 20 to 30 weeks, recognizable tooth structures formed that contained dentin, odontoblasts, a well-defined pulp chamber, putative Hertwig’s root sheath epithelia, putative cementoblasts, and a morphologically correct enamel organ containing fully formed enamel. Our results demonstrate the first successful generation of tooth crowns from dissociated tooth tissues that contain both dentin and enamel, and suggest the presence of epithelial and mesenchymal dental stem cells in porcine third molar tissues.

Key Words: tissue engineering • polymer scaffold • enamel • dentin

Journal of Dental Research, Vol. 81, No. 10, 695-700 (2002)
DOI: 10.1177/154405910208101008
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JDRHome page
G.T.-J. Huang, S. Gronthos, and S. Shi
Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine
Journal of Dental Research, September 1, 2009; 88(9): 792 - 806.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
S.A. Hacking and A. Khademhosseini
Applications of Microscale Technologies for Regenerative Dentistry
Journal of Dental Research, May 1, 2009; 88(5): 409 - 421.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
E. Nakagawa, T. Itoh, H. Yoshie, and I. Satokata
Odontogenic Potential of Post-natal Oral Mucosal Epithelium
Journal of Dental Research, March 1, 2009; 88(3): 219 - 223.
[Abstract] [Full Text] [PDF]

Home page
 Journal of the American Dental AssociationHome page
E. L. Gotlieb, P. E. Murray, K. N. Namerow, S. Kuttler, and F. Garcia-Godoy
An Ultrastructural Investigation of Tissue-Engineered Pulp Constructs Implanted Within Endodontically Treated Teeth
J Am Dent Assoc, April 1, 2008; 139(4): 457 - 465.
[Abstract] [Full Text] [PDF]

Home page
 J Dent EducHome page
H. K. Fong, B. L. Foster, T. E. Popowics, and M. J. Somerman
The Crowning Achievement: Getting to the Root of the Problem
J Dent Educ., May 1, 2005; 69(5): 555 - 570.
[Abstract] [Full Text] [PDF]

Home page
 J Dent EducHome page
S. C. Bayne
Dental Biomaterials: Where Are We and Where Are We Going?
J Dent Educ., May 1, 2005; 69(5): 571 - 585.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
M. Goldberg and A. J. Smith
CELLS AND EXTRACELLULAR MATRICES OF DENTIN AND PULP: A BIOLOGICAL BASIS FOR REPAIR AND TISSUE ENGINEERING
Critical Reviews in Oral Biology & Medicine, January 1, 2004; 15(1): 13 - 27.
[Abstract] [Full Text] [PDF]