Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Free Full Text Free
Right arrow Free Full Text (Free PDF) Free
Right arrow An erratum has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Das, S.J.
Right arrow Articles by Olsen, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Das, S.J.
Right arrow Articles by Olsen, I.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Biological

Keratinocyte Growth Factor Receptor is Up-regulated in Cyclosporin A-induced Gingival Hyperplasia

S.J. Das1,2, H.N. Newman3 and I. Olsen2,*

1 Department of Periodontology, Regional Dental College, Guwahati-32, India;
2 Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Gray’s Inn Road, London WCIX 8LD, UK; and
3 Oral Health Research Centre, Parkside National Health Service Trust, London, UK;

Correspondence: * corresponding author, i.olsen{at}eastman.ucl.ac.uk

Keratinocyte growth factor stimulates the growth and activity of epithelial cells via the keratinocyte growth factor receptor. We have recently shown that the growth factor is markedly elevated in cyclosporin A-induced gingival hyperplasia tissue in vivo, but the effects of cyclosporin A on the receptor are not yet known. The present study was therefore carried out to determine whether expression of the keratinocyte growth factor receptor is up-regulated in gingival hyperplasia compared with normal gingiva. Using immunohistochemistry and the reverse-transcribed polymerase chain-reaction, we obtained results which showed that receptor antigen and gene transcript levels were both elevated in gingival hyperplasia tissue. In addition, flow cytometry and the reverse-transcribed polymerase chain-reaction showed that the receptor and mRNA were also higher in gingival epithelial cells following incubation with cyclosporin A in vitro. These findings suggest that the keratinocyte growth factor-receptor pathway of mesenchymal-epithelial interaction could play an important part in the molecular pathogenesis of gingival hyperplasia.

Key Words: gingiva • hyperplasia • keratinocyte growth factor receptor • epithelial cells

Journal of Dental Research, Vol. 81, No. 10, 683-687 (2002)
DOI: 10.1177/154405910208101006
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
A. Vitsky, J. Waire, R. Pawliuk, A. Bond, D. Matthews, E. LaCasse, M. L. Hawes, C. Nelson, S. Richards, P. A. Piepenhagen, et al.
Homeostatic Role of Transforming Growth Factor-{beta} in the Oral Cavity and Esophagus of Mice and Its Expression by Mast Cells in These Tissues
Am. J. Pathol., June 1, 2009; 174(6): 2137 - 2149.
[Abstract] [Full Text] [PDF]