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Journal of Dental Research
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Biological

Expression of MMP-8 and MMP-13 mRNAs in Rat Periodontium during Tooth Eruption

M. Tsubota1, Y. Sasano2,*, I. Takahashi3, M. Kagayama2 and H. Shimauchi1

1 Division of Periodontics and Endodontics, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan;
2 Division of Oral Molecular Biology, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan; and
3 Division of Orthodontics, Tohoku University Graduate School of Dentistry, Sendai 980-8575, Japan;

Correspondence: * corresponding author, sasano{at}anat.dent.tohoku.ac.jp

The present study was designed to investigate mRNA expression of matrix metalloproteinase-8 (MMP-8) and MMP-13 in forming periodontium during tooth eruption in the rat. RT-PCR for the decalcified paraffin sections indicated expression of MMP-8 and MMP-13 in the periodontal tissues. In situ hydridization demonstrated expression of MMP-8 in osteoblasts, osteocytes, periodontal ligament cells, cementoblasts, and cementocytes along with collagen types I and III. In contrast, transcripts of MMP-13 were confined to a small population of osteoblasts and osteocytes in alveolar bone. The results suggested that MMP-8 may be involved in remodeling the periodontium during tooth eruption, and its expression may be coordinated with that of collagen types I and III, whereas the participation of MMP-13 may be rather limited.

Key Words: collagenase • collagen • periodontal ligament • in situ hybridization • RT-PCR

Journal of Dental Research, Vol. 81, No. 10, 673-678 (2002)
DOI: 10.1177/154405910208101004
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