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Journal of Dental Research
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Clinical

Levels of GM-CSF, IL-3, and IL-6 in Fluid and Tissue from Human Radicular Cysts

A.M. Gervásio1, D.A.O. Silva1, E.A. Taketomi1, C.J.A. Souza2, S-S.J. Sung3 and A.M. Loyola*,4

1 Division of Immunology, Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia (MG), Brazil;
2 Department of Clinic and Operative Dentistry and Endodontics, School of Dentistry, Federal University of Uberlândia, Uberlândia (MG), Brazil;
3 Division of Rheumatology, Health Sciences Center, University of Virginia, Charlottesville, VA, USA; and
4 Department of Oral and Maxillofacial Pathology, School of Dentistry, Federal University of Uberlândia, Av. Pará, 1720, CEP 38405-902, Uberlândia (MG), Brazil;

Correspondence: *corresponding author, passaro{at}ufu.br

Cytokines released by immune system cells play an important role in cyst enlargement. This study aimed to determine, by ELISA, the levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin 3 (IL-3), and IL-6 in fluid and tissue from human radicular cysts. GM-CSF was found in 42.8% of the fluid samples (164.3 pg/mL) and IL-6 in 92.8% (641.4 pg/mL). No IL-3 was detected in any fluid samples. In the tissue samples, 28.6% were positive for IL-3 (369.2 pg/mL), 86.4% for IL-6 (92.4 pg/mL), and 95.8% for GM-CSF (200.5 pg/mL). It can be concluded that GM-CSF and IL-6 were widely found in the fluid and tissue samples. In contrast, IL-3 was found only in the cystic tissue, even though in few lesions. These cytokines may contribute to the inflammation, cystic growth, and bone resorption that characterize cystic lesions.

Key Words: odontogenic cyst • radicular cyst • periapical lesion • cytokines • bone resorption

Journal of Dental Research, Vol. 81, No. 1, 64-68 (2002)
DOI: 10.1177/154405910208100114
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