Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Childers, N.K.
Right arrow Articles by Michalek, S.M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Childers, N.K.
Right arrow Articles by Michalek, S.M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Clinical

Humans Immunized with Streptococcus mutans Antigens by Mucosal Routes

N.K. Childers*,1, G. Tong1, F. Li1, A.P. Dasanayake2, K. Kirk3 and S.M. Michalek4

1 Department of Pediatric Dentistry and
2 Oral Biology, School of Dentistry, Room 308, 1530 3rd Ave. South, University of Alabama at Birmingham, Birmingham, AL, USA 35294-0007;
3 Department of Biostatistics, School of Public Health, University of Alabama at Birmingham; and
4 Department of Microbiology, University of Alabama at Birmingham;

Correspondence: *corresponding author, nkc{at}uab.edu

Strategies aimed at the prevention of Streptococcus mutans infection and dental caries include mucosal immunization, which results in salivary anti-S. mutans responses. The purpose of this study was to evaluate the effectiveness of nasal vs. tonsillar immunization with S. mutans antigens in inducing salivary immune responses. Twenty-one adult subjects were immunized twice, within a seven-day interval, with a glucosyltransferase-enriched preparation (E-GTF) administered by nasal or tonsillar topical spray. Parotid saliva, nasal wash, and serum were collected prior to and at one- to two-week intervals for 3 months following immunization and were assayed by ELISA for anti-E-GTF activity. Results were analyzed by means of the mixed-models procedure with p < 0.05 level of significance. Significantly higher anti-E-GTF responses were detected in saliva and nasal wash samples from the group immunized by the nasal compared with the tonsillar route, indicating that nasal immunization was more effective in inducing mucosal responses in adults.

Key Words: mucosal immunity • immunization • caries • liposomes • Streptococcus mutans

Journal of Dental Research, Vol. 81, No. 1, 48-52 (2002)
DOI: 10.1177/154405910208100111
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Histochem. Cytochem.Home page
A. Carapelli, M. Regoli, C. Nicoletti, L. Ermini, L. Fonzi, and E. Bertelli
Rabbit Tonsil-associated M-cells Express Cytokeratin 20 and Take Up Particulate Antigen
J. Histochem. Cytochem., October 1, 2004; 52(10): 1323 - 1332.
[Abstract] [Full Text] [PDF]