Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Dental Research
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Yamashiro, T.
Right arrow Articles by Takano-Yamamoto, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamashiro, T.
Right arrow Articles by Takano-Yamamoto, T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Activation of the Bulbospinal Serotonergic System during Experimental Tooth Movement in the Rat

T. Yamashiro

Department of Orthodontics, Okayama University Graduate School of Medicine and Dentistry

T. Fukunaga

Department of Orthodontics, Okayama University Graduate School of Medicine and Dentistry

H. Kabuto

Department of Brainscience, Okayama University Graduate School of Medicine and Dentistry, 2-5-1, Shikata-cho, Okayama 700-8525, Japan, Department of Medical Technology, Kagawa Prefectural College of Health Sciences, 281-1 Hara, Mure-cho, Kita-gun, Kagawa 761-1202, Japan

N. Ogawa

Department of Brainscience, Okayama University Graduate School of Medicine and Dentistry, 2-5-1, Shikata-cho, Okayama 700-8525, Japan

T. Takano-Yamamoto

Department of Orthodontics, Okayama University Graduate School of Medicine and Dentistry

Experimental tooth movement is known to induce characteristic delayed and continuous nociception. Nociceptive somatic stimuli activate endogenous pain control systems such as descending monoaminergic pathways, which modulate the transmission of ascending sensory messages. To test the hypothesis that bulbospinal serotonergic pathways modulate subchronic nociception, we assayed the medulla at the level of the subnucleus caudalis and peri-aqueductal grey by high-performance liquid chromatography with electrochemical detection for the serotonin (5-hydroxytryptamine, 5-HT) and its metabolite (5-hydroxyindoleacetic acid, 5-HIAA) 24 hrs after the onset of experimental tooth movement. Experimental tooth movement significantly increased 5-HT and 5-HIAA levels, and 5-HIAA/5-HT, an index of serotonin turnover, in the medulla, and 5-HIAA level and 5-HIAA/5-HT in the peri-aqueductal grey, indicating that nociception induced by experimental tooth movement activates the bulbospinal serotonergic pathway.

Key Words: tooth movement • serotonin • 5-HT • 5-HIAA • peri-aqueductal grey • medulla.

Journal of Dental Research, Vol. 80, No. 9, 1854-1857 (2001)
DOI: 10.1177/00220345010800091601
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Eur J OrthodHome page
V. Krishnan
Orthodontic pain: from causes to management--a review
Eur J Orthod, April 1, 2007; 29(2): 170 - 179.
[Abstract] [Full Text] [PDF]