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Journal of Dental Research
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Mercury Uptake and Kinetics after Ingestion of Dental Amalgam

E. af Geijersstam

Dept. of Basic Oral Sciences, School of Dentistry, Karolinska Institutet, PO Box 4064, S-141 04 Huddinge, Swedengunilla.sandborgh{at}ofa.ki.se

G. Sandborgh-Englund

Dept. of Basic Oral Sciences, School of Dentistry, Karolinska Institutet, PO Box 4064, S-141 04 Huddinge, Sweden,

F. Jonsson

Toxicology and Risk Assessment, National Institute for Working Life, Stockholm, Sweden

J. Ekstrand

Dept. of Basic Oral Sciences, School of Dentistry, Karolinska Institutet, PO Box 4064, S-141 04 Huddinge, Sweden

The aim of the present study was to investigate the G-I uptake of mercury (Hg) after intake of a single dose of amalgam-Hg, followed by pharmacokinetic analysis of the data. Eleven volunteers without amalgam fillings ingested 1.00 g amalgam powder. Hg in plasma vs. time was analyzed with a two-compartment model by means of mixed-effects modeling. A fraction of the absorption rate of Hg to the central compartment was inversely proportional to the plasma ferritin levels. The population mean half-life of the terminal phase of Hg in plasma was 37 days, with a considerable standard deviation in the population. The absorbed fraction of the administered dose was estimated to be about 0.04%. It is concluded that the G-I uptake of Hg is of quantitative importance during dental treatment.

Key Words: plasma • absorption • human • oral administration • pharmacokinetics

Journal of Dental Research, Vol. 80, No. 9, 1793-1796 (2001)
DOI: 10.1177/00220345010800090401
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