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Journal of Dental Research
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Growth-hormone-stimulated Dentinogenesis in Lewis Dwarf Rat Molars

W.G. Young

Department of Oral Biology, School of Dentistry, The University of Queensland, Brisbane, QLD 4072, Australia

H. Li

Department of Oral Biology, School of Dentistry, The University of Queensland, Brisbane, QLD 4072, Australia

Y. Xiao

Department of Oral Biology, School of Dentistry, The University of Queensland, Brisbane, QLD 4072, Australia

M.J. Waters

Department of Physiology & Pharmacology, The University of Queensland, Brisbane, QLD 4072, Australia

P.M. Bartold

Department of Oral Biology, School of Dentistry, The University of Queensland, Brisbane, QLD 4072, Australia, p.bartold{at}mailbox.uq.edu.au

In dentinogenesis, certain growth factors, matrix proteoglycans, and proteins are directly or indirectly dependent on growth hormone. The hypothesis that growth hormone up-regulates the expression of enzymes, sialoproteins, and other extracellular matrix proteins implicated in the formation and mineralization of tooth and bone matrices was tested by the treatment of Lewis dwarf rats with growth hormone over 5 days. The molar teeth were processed for immunohistochemical demonstration of bone-alkaline phosphatase, bone morphogenetic proteins-2 and -4, osteocalcin, osteopontin, bone sialoprotein, and Ell protein. Odontoblasts responded to growth hormone by more cells expressing bone morphogenetic protein, alkaline phosphatase, osteocalcin, and osteopontin. No changes were found in bone sialoprotein or E11 protein expression. Thus, growth hormone may stimulate odontoblasts to express several growth factors and matrix proteins associated with dentin matrix biosynthesis in mature rat molars.

Key Words: growth hormone • dentin matrix • teeth.

Journal of Dental Research, Vol. 80, No. 8, 1742-1747 (2001)
DOI: 10.1177/00220345010800081201
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