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IL-1 Genotype and Adult Periodontitis among Young New Zealanders

Department of Oral Health, School of Dentistry, PO Box 647, The University of Otago, Dunedin, New Zealand, mthomson{at}gandalf.otago.ac.nz

S.J. Edwards

Department of Pathology, Dunedin School of Medicine, The University of Otago

D.P. Dobson-Le

Department of Pathology, Dunedin School of Medicine, The University of Otago

G.R. Tompkins

Department of Oral Sciences and Orthodontics, School of Dentistry, The University of Otago

R. Poulton

Department of Preventive and Social Medicine, Dunedin School of Medicine, The University of Otago

D.A. Knight

Department of Pathology, Dunedin School of Medicine, The University of Otago

A.W. Braithwaite

Department of Pathology, Dunedin School of Medicine, The University of Otago

Several recent studies have investigated the association between interleukin-1 genotype and periodontitis in clinical samples, where generalizability is an issue. The aim of this study was to investigate the association between adult periodontitis and IL-1 genotype in a population-based sample of 26-year-olds. Based on probing depth (PD) measurements, participants were divided into three disease groups: "Severe" (1+ teeth with 5+mm PD; N = 25), "Moderate" (2+ teeth with 4+mm PD; N = 36), and "Controls" (the remainder ; N = 800). The "periodontitis-associated genotype" (PAG; Kornman et al., 1997) was present in 20.0% of the "Severe" group and in 34.8% of "Controls", whereas the IL-1A⁺⁴⁸⁴⁵ [1, 1]/IL-1B⁺³⁹⁵³ [2,2] genotype was present in 12.0% and 0.9%, respectively. After controlling for sex, smoking status, and plaque levels, we found that those with IL-1B⁺³⁹⁵³ [1,1]/IL-1A⁺⁴⁸⁴⁵ [2,2] had 12.3 times the odds of being in the "Severe" group. Analysis of these data suggests that the IL-1A⁺⁴⁸⁴⁵ [1,1]/IL-1B⁺³⁹⁵³ [2,2] genotype is associated with periodontal disease in this young population. Future periodontal data collections as this cohort ages are required to confirm the predictive value of that genotype.

Key Words: periodontal diseases • young adults • gene polymorphism • interleukins.

Journal of Dental Research, Vol. 80, No. 8, 1700-1703 (2001)
DOI: 10.1177/00220345010800080401


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