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Journal of Dental Research
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Salivary Non-immunoglobulin Agglutinin Inhibits Human Leukocyte Elastase Digestion of Acidic Proline-rich Salivary Proteins

R.J. Boackle

Division of Oral Biology, Department of Stomatology, Medical University of South Carolina, 173 Ashley Ave., Charleston, SC 29425

S.L. Dutton

Division of Oral Biology, Department of Stomatology, Medical University of South Carolina, 173 Ashley Ave., Charleston, SC 29425

H. Fei

Division of Oral Biology, Department of Stomatology, Medical University of South Carolina, 173 Ashley Ave., Charleston, SC 29425

J. Vesely

Division of Oral Biology, Department of Stomatology, Medical University of South Carolina, 173 Ashley Ave., Charleston, SC 29425

D. Malamud

Department of Biochemistry, School of Dental Medicine, University of Pennsylvania

A.R. Furness

Division of Oral Biology, Department of Stomatology, Medical University of South Carolina, 173 Ashley Ave., Charleston, SC 29425

Saliva contains acidic proline-rich salivary proteins that are involved in the formation of the salivary pellicle coating supragingival tooth surfaces. However, human leukocyte elastase, arriving in gingival exudates from inflamed periodontal tissues, degrades the acidic proline-rich salivary proteins, preventing binding to hydroxylapatite surfaces. Here it is reported that high-molecular-weight non-immunoglobulin salivary agglutinin inhibited the proteolytic action of human leukocyte elastase on purified acidic proline-rich salivary proteins. Inhibition was eliminated with monoclonal antibody to a protein determinant on the salivary agglutinin. The addition of antibody against salivary agglutinin blocked the inhibitory effect of parotid saliva on exogenously applied human leukocyte elastase, allowing for the elastase-mediated digestion of the salivary acidic proline-rich salivary proteins. Salivary agglutinin, therefore, is a physiologically important inhibitor of human leukocyte elastase and is able to inhibit elastase-mediated digestion of salivary acidic proline-rich proteins.

Key Words: high molecular weight non-immunoglobulin salivary agglutinin (salivary agglutinin) • human leukocyte elastase • acidic salivary proline-rich proteins • salivary leukocyte protease inhibitor • periodontal disease • human immunodeficiency virus.

Journal of Dental Research, Vol. 80, No. 6, 1550-1554 (2001)
DOI: 10.1177/00220345010800061401
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